1-Methylindazole-3-Carboxylic Acid CAS 50890-83-0 Purity >99.0% (HPLC) Granisetron Hydrocholride Intermediate Factory

Short Description:

Chemical Name: 1-Methylindazole-3-Carboxylic Acid

Synonyms: 1-Methyl-1H-Indazole-3-Carboxylic Acid

CAS: 50890-83-0

Purity: >99.0% (HPLC) (T)

Appearance: White to Off-White Crystalline Powder

Intermediate of Granisetron Hydrocholride (CAS: 107007-99-8)

High Quality, Commercial Production

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Product Detail

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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 1-Methylindazole-3-Carboxylic Acid (CAS: 50890-83-0) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	1-Methylindazole-3-Carboxylic Acid
Synonyms	1-Methyl-1H-Indazole-3-Carboxylic Acid
Impurity	Granisetron Related Compound D; Granisetron EP Impurity D
CAS Number	50890-83-0
CAT Number	RF2673
Stock Status	In Stock, Production Capacity 25 Tons per Month
Molecular Formula	C9H8N2O2
Molecular Weight	176.18
Melting Point	213.0~218.0℃
Boiling Point	383.7±15.0℃
Density	1.35±0.1 g/cm
Solubility in Water	Insoluble in Water. Soluble in DMSO and Methanol
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Purity / Analysis Method	>99.0% (HPLC Area)
Purity / Analysis Method	99.0~102.5% (Titration by NaOH)
Melting Point	213.0~218.0℃
Loss on Drying	<0.50%
Sulfated Ash	<0.10%
Related Substances
Indazole Acid	<0.50%
2-Methylindazole Acid	<0.50%
Other Single Impurity	<0.50%
Total Related Impurities	<1.00%
Infrared Spectrum	Conforms to Structure
Proton NMR Spectrum	Conforms to Structure
Test Standard	Enterprise Standard
Usage	Intermediate of Granisetron Hydrocholride (CAS: 107007-99-8)

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Russia, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

1-Methylindazole-3-Carboxylic Acid (CAS: 50890-83-0) is an intermediate of Granisetron Hydrocholride (CAS: 107007-99-8). Granisetron Hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Factors such as radiotherapy, chemotherapy and surgery can induce the release of 5-HT from intestinal chromaffin cells, and 5-HT may activate the 5-HT3 receptor in the central or vagus nerve and cause vomiting reflex. The mechanism of nausea and vomiting controlled by this product is the inhibition of nausea and vomiting by antagonizing 5-HT3 receptors in the central chemoreceptor area and peripheral vagal terminals.Granisetron Hydrochloride has high selectivity, no extrapyramidal reaction, excessive sedation and other side effects.