4-Fluoro-2-Methoxy-5-Nitroaniline CAS 1075705-01-9 Purity >99.0% (HPLC) Osimertinib (AZD-9291) Mesylate Intermediate

Short Description:

Name: 4-Fluoro-2-Methoxy-5-Nitroaniline

CAS: 1075705-01-9

Purity: >99.0% (HPLC)

Appearance: Brown Crystalline Powder

Intermediate of Osimertinib (AZD-9291) Mesylate

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

1075705-01-9 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Fluoro-2-Methoxy-5-Nitroaniline (CAS: 1075705-01-9) with high quality, intermediate of Osimertinib (AZD-9291) Mesylate (CAS: 1421373-66-1). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Osimertinib (AZD-9291) Mesylate intermediates, Please contact: alvin@ruifuchem.com

1075705-01-9 - Chemical Properties:

Chemical Name	4-Fluoro-2-Methoxy-5-Nitroaniline
Synonyms	AZD-9291 Intermediate; 2-Amino-5-Fluoro-4-Nitroanisole, 4-Fluoro-5-Nitro-o-Anisidine;4-Fluoro-2-Methoxy-5-Nitrobenzenamine
Stock Status	In Stock, Production Capacity 100 Tons per Year
CAS Number	1075705-01-9
Molecular Formula	C7H7FN2O3
Molecular Weight	186.14 g/mol
Melting Point	128.0 to 132.0℃
Density	1.412±0.06 g/cm3
Store Under Inert Gas	Store Under Inert Gas (Nitrogen or Argon) at 2~8℃
Sensitive	Air Sensitive
COA & MSDS	Available
Place of Origin	Shanghai, China
Shelf Life	2 Years When Properly Stored
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

1075705-01-9 - Specifications:

Items	Specifications	Results
Appearance	Brown Crystalline Powder	Brown Crystalline Powder
Identification	The Retention Time of Test Sample Major Peak Complies to Reference Standard	Conforms
Purity / Analysis Method	>99.0% (HPLC Area)	99.72%
Total Impurities	<1.00%	0.28%
Melting Point	128.0~132.0℃	130.2℃
Water by Karl Fischer	<0.50%	0.21%
Infrared Spectrum	Conforms to Structure	Conforms
NMR Spectrum 1H	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Osimertinib (AZD-9291) Mesylate (CAS: 1421373-66-1)

Note: This product is for scientific research only and shall not be used for other purposes.

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

1075705-01-9 - Application:

4-Fluoro-2-Methoxy-5-Nitroaniline (CAS: 1075705-01-9) is used as pharmaceutical intermediates, intermediate of Osimertinib (AZD-9291) Mesylate (CAS: 1421373-66-1). AZD-9291 Mesylate is a potent and selective epidermal growth factor receptor (EGFR) inhibitor. AZD-9291 Mesylate is suitable for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have progressed during or after treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) and have been confirmed to have EGFR T790M mutation positive. AZD-9291 Mesylate is highly selective.