4-Ethyl-5-Fluoro-6-Hydroxypyrimidine CAS 137234-87-8 Purity ≥99.0% (HPLC) Voriconazole Intermediate Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Ethyl-5-Fluoro-6-Hydroxypyrimidine (CAS: 137234-87-8) with high quality, intermediate of Voriconazole (CAS: 137234-62-9). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Voriconazole Intermediates, Please contact: alvin@ruifuchem.com
| Chemical Name | 4-Ethyl-5-Fluoro-6-Hydroxypyrimidine |
| Synonyms | 6-Ethyl-5-Fluoropyrimidin-4(3H)-one; 6-Ethyl-5-Fluoro-4(1H)-Pyrimidinone; 6-Ethyl-5-Fluoro-4-Hydroxypyrimidine; 6-Ethyl-5-Fluoropyrimidin-4(1H)-one; 4-Hydroxy-5-Fluoro-6-Ethylpyrimidine |
| CAS Number | 37234-87-8 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C6H7FN2O |
| Molecular Weight | 142.13 |
| Melting Point | 114.0~116.0℃ |
| Density | 1.30±0.10 g/cm3 |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Specifications | Results |
| Appearance | White to Off-White Powder or Crystals | Conforms |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.28% |
| Moisture (K.F) | ≤1.00% | 0.26% |
| Total Impurities | ≤1.00% | 0.72% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| NMR Spectrum | Conforms to Structure | Conforms |
| Test Standard | Enterprise Standard | Conforms |
| Application | Intermediate of Voriconazole (CAS: 137234-62-9) | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Risk Codes
R22 - Harmful if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description
S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
Hazard Class IRRITANT
4-Ethyl-5-Fluoro-6-Hydroxypyrimidine (CAS: 137234-87-8) is a pyrimidine derivative used in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents. 4-Ethyl-5-Fluoro-6-Hydroxypyrimidine is the intermediate of Voriconazole (CAS: 137234-62-9). Voriconazole is a broad-spectrum triazole antifungal, it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus.
