2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6 Linagliptin Intermediate Purity ≥99.0% (HPLC)

Short Description:

Chemical Name: 2-(Chloromethyl)-4-Methylquinazoline

CAS: 109113-72-6

Purity: ≥99.0% (HPLC)

Appearance: Pale Yellow to Pale Brown Powder

Intermediate for Linagliptin (CAS: 668270-12-0) for the treatment of adults with type 2 diabetes mellitus.

High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Manufacturer Supply Linagliptin and Related Intermediates:
Linagliptin CAS 668270-12-0
Linagliptin Parent Nucleus Intermediate CAS 853029-57-9
8-Bromo-3-Methylxanthine CAS 93703-24-3
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine CAS 666816-98-4
2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6
(R)-3-(Boc-Amino)piperidine CAS 309956-78-3
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
1-Bromo-2-Butyne CAS 3355-28-0

Chemical Properties:

Chemical Name	2-(Chloromethyl)-4-Methylquinazoline
Synonyms	Linagliptin Intermediate A
CAS Number	109113-72-6
CAT Number	RF-PI498
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C10H9ClN2
Molecular Weight	192.64
Density	1.251
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Pale Yellow to Pale Brown Powder
Identification A	The sample IR spectrum must match with the standard spectrum
Identification B	The retention time of principle peak of the sample must correspond to standard
Solubility	Soluble in Methylene Chloride; Insoluble in Water
Purity / Analysis Method	≥99.0% (HPLC)
Melting Point	60.0 to 65.0℃
Water (K.F)	≤0.50%
Residue on Ignition	≤0.50%
Related Substances
Single Impurity	≤0.30%
Total Impurities	≤1.0%
Test Standard	Enterprise Standard
Usage	Intermediate for Linagliptin (CAS: 668270-12-0)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Advantages:

FAQ:

Application:

2-(Chloromethyl)-4-Methylquinazoline (CAS: 109113-72-6) is used as an intermediate for the preparation of Linagliptin (CAS: 668270-12-0), and its impurities. Linagliptin, sold under the brand name Tradjenta among others, is a medication used to treat diabetes mellitus type 2. It is generally less preferred than metformin and sulfonylureas as an initial treatment. It is used together with exercise and diet. It is not recommended in type 1 diabetes. It works by increasing the production of insulin and decreasing the production of glucagon by the pancreas. Linagliptin was approved for medical use in the United States in 2011. Linagliptin is a highly potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 1 nM.