3-Chloro-4-Fluoroaniline CAS 367-21-5 Gefitinib Intermediate Purity >99.5% (HPLC)

Short Description:

Chemical Name: 3-Chloro-4-Fluoroaniline 

CAS: 367-21-5

Purity: >99.5% (HPLC)

Appearance: White to Off-White Crystals 

Intermediate of Gefitinib (CAS: 184475-35-2)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 3-Chloro-4-Fluoroaniline (CAS: 367-21-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 3-Chloro-4-Fluoroaniline, Please contact: alvin@ruifuchem.com

Gefitinib Intermediates:

Chemical Properties:

Chemical Name 3-Chloro-4-Fluoroaniline  
Synonyms 4-Fluoro-3-Chloroaniline; 3-Chloro-4-Fluorobenzenamine; m-Chloro-p-Fluoroaniline
Stock Status In Stock, Commercial Production  
CAS Number 367-21-5
Molecular Formula C6H5ClFN 
Molecular Weight 145.56 g/mol
Melting Point 42.0~47.0℃(lit.) 
Boiling Point 227.0~230.0℃(lit.)
Flash Point 110℃
Density 1.226 g/cm3
Stability Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White to Off-White Crystals Off-White Crystals 
Water by Karl Fischer  <0.50% 0.19% 
Residue on Ignition <0.10% <0.10%  
Single Impurity <0.50% 0.09%
Total impurities <0.50% 0.30%
Purity / Analysis Method >99.5% (HPLC)  99.7% 
1H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory AuditFactory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
TransportationBy Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom SynthesisCan provide custom synthesis services to best fit your research needs.
Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

367-21-5 - Safety Information:

Risk Codes R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R33 - Danger of cumulative effects
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs UN 2811 6.1/PG 2
WGK Germany 2
FLUKA BRAND F CODES 9-23
TSCA T
HS Code 29214200.90
Hazard Note Irritant/Toxic
Hazard Class 6.1
Packing Group III
Toxicity LD50 orally in Rabbit: 506 mg/kg

367-21-5 - Application:

3-Chloro-4-Fluoroaniline (CAS: 367-21-5) is used as an organic synthesis intermediate, pharmaceutical intermediate, or chemical reagent.  

3-Chloro-4-Fluoroaniline is an important starting material of Gefitinib (CAS: 184475-35-2). Gefitinib is an antineoplastic target therapy drug with relatively high specificity that was developed by the British pharmaceutical company AstraZeneca; it is the first molecular targeted drug to be used in non-small cell lung cancer treatment.

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