3-Ethynylaniline CAS 54060-30-9 Purity >99.0% (GC) Erlotinib Hydrochloride Intermediate

3-Ethynylaniline, also known as 3-Aminophenylacetylene (CAS: 54060-30-9) is used as a pharmaceutical intermediate. 3-Ethynylaniline is an intermediate of Erlotinib Hydrochloride (CAS: 183319-69-9). Erlotinib Hydrochloride is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal growth receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcitabine as a first-line treatment for locally advanced and metastatic pancreatic cancer. It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment. Erlotinib Hydrochloride, a quinazoline derived small molecule inhibitor of epidermal growth receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer.