4-Amino-3-Chlorophenol CAS 17609-80-2 Lenvatinib Mesylate Intermediate Purity >99.0% (HPLC)

4-Amino-3-Chlorophenol (CAS: 17609-80-2) is an important pharmaceutical intermediate, which is widely used in the design and synthesis of anti-tumor, cardiovascular diseases, neurological diseases drugs. 4-Amino-3-Chlorophenol is an important intermediate in the preparation of Lenvatinib Mesylate (CAS: 857890-39-2). Developed by Eisai Inc., lenvatinib mesylate is a vascular endothelial growth factor receptor (VEGF) inhibitor which has activity against VEGF subtypes 1, 2, and 3 and was approved by the FDA in 2015 for the treatment of differentiated thyroid cancer that is either locally recurrent, metastatic, or progressive and did not respond to radioactive iodine treatment. In May 2016, the FDA approved the drug as a combination therapy with everolimus for the treatment of advanced renal cell carcinoma. Because VEGF (and fibroblast growth factor receptors, known as FGFRs) are thought to play a role in cardiovascular signaling pathways, VEGF2R and FGFR inhibition are thought to be the mechanisms behind the primary side effect of lenvatinib mesylate, which is hypertension.