4-Aminosalicylic Acid CAS 65-49-6 Purity >99.0% (HPLC) (T) Factory

4-Aminosalicylic Acid (4-ASA) (CAS: 65-49-6), an aminobenzoic acid that is salicylic acid substituted by an amino group at position 4, is one of the last remaining drugs available to treat extensively drug-resistant (XDR) tuberculosis. It is an antitubercular agent often administered in association with Isoniazid. 4-Aminosalicylic Acid exhibits anti-inflammatory, antioxidative, and antibacterial activities; it is clinically used to treat inflammatory bowel disease (IBD), Crohn’s disease, and colitis, as it acts primarily in the colon. It is typically taken by mouth. 4-Aminosalicylic Acid is used against Mycobacterium as a treatment for tuberculosis; it inhibits dihydrofolate reductase (DHFR) activity as an antimetabolite. 4-Aminosalicylic Acid, an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. 4-Aminosalicylic Acid can be used in the synthesis of: Azo derivatives of 4-ASA with anti-inflammatory effects; Ammonium 4-aminosalicylate salt polymorphs which are used as pharmaceutical ingredients; Salicylic acid-triazole analogs which are used as quorum sensing inhibitors against Pseudomonas aeruginosa.