4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS 327-78-6 Purity ≥99.0% Sorafenib Tosylate Intermediate Factory
Commercial Supply Sorafenib Tosylate and Related Intermediates:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Name | 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate |
| Synonyms | Isocyanic Acid 4-Chloro-3-(Trifluoromethyl)phenyl Ester |
| CAS Number | 327-78-6 |
| CAT Number | RF-PI167 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 |
| Melting Point | 37.0~42.0℃ (lit.) |
| Boiling Point | 86.0~90.0℃ 14 mmHg (lit.) |
| Density | 1.4720 |
| Shipping Conditions | Ambient |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White Crystalline |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Identification | (1) IR (2) HPLC |
| Moisture (K.F) | ≤0.50% |
| Heavy Metals | ≤10ppm |
| Impurity A | ≤0.15% |
| Impurity B | ≤1.0% |
| Impurity C | ≤1.0% |
| Other Single Impurity | ≤0.50% |
| Total Impurities | ≤1.0% |
| Residual Solvent | Toluene ≤0.089% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Sorafenib Tosylate (CAS: 475207-59-1) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Manufacturer with High Purity and Stable Quality
Commercial Supply Sorafenib Tosylate (CAS: 475207-59-1) Related Intermediates:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
Sorafenib Tosylate (CAS: 475207-59-1) is a new type of multi-target antitumor drug, was developed by the German Bayer Pharmaceuticals, and displayed expansive antitumor activity in preclinical animal tests. Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and HCC. Sorafenib Tosylate (CAS: 475207-59-1) can simultaneously affect tumor cells and tumor blood vessels. It has a double antitumor effect: it can block the cell signal transduction pathways mediated by RAF/MEK/ERK to directly inhibit tumor cell growth, while also inhibiting VEGF and platelet derived growth factors (PDGF) receptors to prevent the formation of new tumor blood vessels, thus indirectly inhibiting tumor cell growth.
