4-Dimethylaminopyridine DMAP CAS 1122-58-3 Purity >99.0% (HPLC) Highly Efficiency Catalyst

4-Dimethylaminopyridine (DMAP) (CAS: 1122-58-3) is a new highly efficiency catalyst widely used in chemical synthesis. It has high catalytic capacity in organic synthesis, drug synthesis, pesticide, dye, fragrance synthesis of acylation, alkylation, etherification and other types of reaction, and has a very obvious effect on improving yield. Acylation of alcohol; Acylation of phenols; Acylation of amines; Acylation of enolates; Reactions of isocyanates; Miscellaneous Applications; Transfer of Functional Groups.
DMAP, is a super nucleophilic acylation catalyst. The resonance of the electron-donating dimethylamino group in its structure and the parent ring (pyridine ring) can strongly activate the nitrogen atom on the ring to undergo nucleophilic substitution, which significantly catalyzes high resistance, low-reactive alcohols and amines/acids The activity of the acylation/esterification reaction is about 104~106 times that of pyridine. Acyl transfer is a common transformation in nature and organic synthesis, in which chiral DMAP is a common asymmetric acyl transfer catalyst. Since 1996, Vedejs and Fu team reported the central chiral and planar chiral DMAP catalysts respectively, chiral DMAP catalysts have been greatly developed. Various central chiral, planar chiral, spiro chiral and central chiral DMAP have been reported one after another, and have been well applied in many asymmetric acyl transfer reactions.
DMAP is a highly versatile nucleophilic catalyst for acylation reactions and esterifications. It is also employed in various organic transformations like Baylis-Hillman reaction, Dakin-West reaction, protection of amines, C-acylations, silylations, applications in natural products chemistry, and many others.
DMAP can be used as a catalyst: For the acylation of alcohols with acid anhydrides under auxiliary base- and solvent-free conditions to synthesize corresponding esters. In Baylis-Hillman reaction to form carbon-carbon bond by the coupling of an activated alkene with an aldehyde or ketone.
A highly efficient catalyst for acylation reactions.