4-(Methylthio)phenylacetic Acid CAS 16188-55-9 Purity >98.0% (GC) Etoricoxib Intermediate
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| Chemical Name | 4-(Methylthio)phenylacetic Acid |
| Synonyms | 4-Methylthiophenylacetic Acid; 2-(4-(Methylthio)phenyl)acetic Acid; 2-[4-(Methylsulfanyl)phenyl]acetic Acid; 4-(Methylthio)benzeneacetic Acid |
| CAS Number | 16188-55-9 |
| CAT Number | RF-PI1183 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C9H10O2S |
| Molecular Weight | 182.24 |
| Melting Point | 96.0~99.0℃ (lit.) |
| Boiling Point | 337.4±25.0℃ (lit.) |
| Density | 1.23±0.10 g/cm3 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Light Yellow Powder |
| Purity / Analysis Method | >98.0% (GC) |
| Purity / Analysis Method | >98.0% (Neutralization Titration) |
| Melting Point | 96.0~99.0℃ |
| Loss on Drying | <1.00% |
| Residue on Ignition | <0.50% |
| Total Impurities | <2.00% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Etoricoxib (CAS: 202409-33-4) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
4-(Methylthio)phenylacetic Acid (CAS: 16188-55-9) is the key intermediate for the preparation of Etoricoxib (CAS: 202409-33-4). Etoricoxib is a kind of highly selective cyclooxygenase-2 (COX-2) inhibitors developed by the Merck company with the chemical name being 5-chloro-6'-methyl-3-4-(methanesulfonamide) phenyl]-2, 3'-bipyridine. Etoricoxib has a unique chemical structure that is methylsulfonyl group. The introduction of this group can not only increase the selectivity for COX-2 drugs, but also does not produce sulfa drugs and cross-allergic reactions. Etoricoxib is widely used in treatment of osteoarthritis (OA), rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, acute gouty arthritis, primary dysmenorrhea and postoperative pain, and other diseases.
