4-Morpholinopiperidine CAS 53617-35-9 Purity >97.0% (HPLC) Alectinib Intermediate
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Morpholinopiperidine (4-(Piperidin-4-yl)morpholine) (CAS: 53617-35-9) with high quality, an important intermediate of Alectinib (CAS: 1256580-46-7).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase 4-Morpholinopiperidine or other products, please contact us by e-mail: alvin@ruifuchem.com
Chemical Name | 4-Morpholinopiperidine |
Synonyms | 4-(Piperidin-4-yl)morpholine; 4-(4-Piperidinyl)morpholine; 4-Piperidin-4-ylmorpholine; 4-(Morpholin-4-yl)piperidine; 4-Piperidin-4-yl-morpholine |
Stock Status | In Stock, Commercial Production |
CAS Number | 53617-35-9 |
Molecular Formula | C9H18N2O |
Molecular Weight | 170.25 g/mol |
Melting Point | 40.0~43.0℃(lit.) |
Boiling Point | 100.0~115.0℃/0.15-0.20 mm Hg(lit.) |
Flash Point | >230°F |
Density | 1.033±0.06 g/cm3 |
Storage Temp. | Store Long-Term in a Cool & Dry Place |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Product Categories |
Pharmaceutical Intermediates |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | Off-White to Light Yellow Solid | Off-White Solid |
Purity / Analysis Method | >97.0% (HPLC) | 98.6% |
Water (by K.F) | <0.50% | 0.03% |
1H NMR Spectrum | Conforms to Structure | Conforms |
Conclusion | The product has been tested and complies with the given specifications | |
Application | Intermediate of Alectinib (CAS: 1256580-46-7) |
Package: Fluorinated Bottle, Aluminium foil bag, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry, and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 3
HS Code 2933322000
Hazard Class IRRITANT
4-Morpholinopiperidine (4-(Piperidin-4-yl)morpholine) (CAS: 53617-35-9) is a heterocyclic organic compound belonging to the piperidine family. 4-Morpholinopiperidine is an important synthetic intermediate in the production of many pharmaceuticals, agrochemicals, and other heterocyclic compounds. It is also used as a reagent in laboratory research.
4-Morpholinopiperidine is used in pharmaceutical research as a building block for designing drugs with various biological activities. 4-Morpholinopiperidine is an important intermediate of Alectinib (CAS: 1256580-46-7).
Alectinib was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate Crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with Crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.
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