6-Bromo-2-Naphthol CAS 15231-91-1 Purity ≥99.0% (HPLC) Nafamostat Mesylate Intermediate Factory
Commercial Supply Nafamostat Mesylate (CAS: 82956-11-4) Related Intermediates
| 4-Guanidinobenzoic Acid Hydrochloride | CAS: 42823-46-1 |
| 6-Bromo-2-Naphthol | CAS: 15231-91-1 |
| 6-Cyano-2-Naphthol | CAS: 52927-22-7 |
| 6-Amidino-2-Naphthol Methanesulfonate | CAS: 82957-06-0 |
| N,N′-Dicyclohexylcarbodiimide (DCC) | CAS: 538-75-0 |
| 4-Dimethylaminopyridine (DMAP) | CAS: 1122-58-3 |
| Chemical Name | 6-Bromo-2-Naphthol |
| Synonyms | 6-Bromonaphthalen-2-ol; 6-Bromo-beta-Naphthol |
| CAS Number | 15231-91-1 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C10H7BrO |
| Molecular Weight | 223.07 |
| Solubility in Methanol | Soluble in Methanol, Almost Transparency |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Pink to Almost White Powder |
| Purity | ≥99.0% (HPLC) |
| Melting Point | 123.0~125.0℃ |
| Moisture (K.F) | ≤0.50% |
| Infrared Spectrum | Consistent with Structure |
| 1 H NMR Spectrum | Consistent with Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Nafamostat Mesylate (CAS: 82956-11-4) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
RTECS QL3365000
HS Code 2907159000
Hazard Note Irritant
Nafamostat Mesylate (CAS: 82956-11-4), an anti-pancreatitis drug was prepared from 4-Guanidinobenzoic Acid Hydrochloride (CAS: 42823-46-1) and 6-Amidino-2-naphthol Methanesulfonate (CAS: 82957-06-0) in the presence of DCC (CAS: 538-75-0) with DMAP (CAS: 1122-58-3)as catalyst with an overall yield of about 28%. 6-Amidino-2-naphthol Methanesulfonate (CAS: 82957-06-0) was prepared from 6-Bromo-2-naphthol (CAS: 15231-91-1) by cyanidation,addition,aminolysis and salt formation.
Nafamostat Mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations.
