7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3 Irinotecan Hydrochloride Intermediate High Purity
Manufacturer Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Chemical Name | 7-Ethyl-10-Hydroxycamptothecin |
| Synonyms | SN-38 |
| CAS Number | 86639-52-3 |
| CAT Number | RF-PI242 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C22H20N2O5 |
| Molecular Weight | 392.41 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Light Yellowish White Crystals Powder |
| Identification (IR, UV) | (1) Ultraviolet ray absorption spectrum accord with the demands (2) Infrared ray absorption spectrum concordant with reference standard spectrum shall comply with approved tests |
| Melting Point | 228.0~235.0℃ |
| Related Substances | ≤1.5% |
| 10-Hydroxycamptothecin | ≤0.30% |
| 7-Cthylcamptothecin | ≤0.70% |
| Maximum Unknown Impurity | ≤0.50% |
| Loss on Drying | ≤1.0% |
| Heavy Metals | ≤10ppm |
| Residue on Ignition | ≤0.10% |
| Clarity of Solution | Clear |
| Assay | ≥98.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediate of Irinotecan |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) with high quality. 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. 7-Ethyl-10-Hydroxycamptothecin (SN-38), is the active metabolite of Irinotecan, a semisynthetic derivative of camptothecin, a quinoline-based alkaloid found in the bark of the Chinese camptotheca tree and the Asian nothapodytes tree. Although 7-Ethyl-10-Hydroxycamptothecin is up to 1,000 times more potent than Irinotecan, it has not been converted into a viable drug candidate because it is insoluble. It is presently being subjected to clinical trials in combination with other moieties which may ultimately allow it to be efficacious as an antineoplastic drug.
