2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl) CAS 76513-69-4 Purity >99.0% (GC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl) (CAS: 76513-69-4) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase SEM-Cl, Please contact: alvin@ruifuchem.com
Chemical Name | 2-(Trimethylsilyl)ethoxymethyl Chloride (Stabilized with Diisopropylethylamine) |
Synonyms | (2-Chloromethoxyethyl)trimethylsilane; Chloromethyl 2-Trimethylsilylethyl Ether; SEM-Cl; SEM-Chloride (Stabilized with Diisopropylethylamine) |
Stock Status | In Stock, Commercial Production |
CAS Number | 76513-69-4 |
Molecular Formula | C6H15ClOSi |
Molecular Weight | 166.72 g/mol |
Boiling Point | 170.0~172.0℃(lit.) 57.0~59.0℃/8 mmHg (lit.) |
Flash Point | 46℃(115°F) |
Density | 0.942 g/mL at 25℃(lit.) |
Refractive Index n20/D | 1.435(lit.) |
Store Under Inert Gas | Store Under Inert Gas (Nitrogen) |
Sensitive | Light Sensitive, Moisture Sensitive, Heat Sensitive |
Water Solubility | Decomposes |
Hydrolytic Sensitivity | 7: Reacts Slowly with Moisture/Water |
Hazard Class | 8 (3); Corrosive, Flammable Liquid |
COA & MSDS | Available |
Place of Origin | Shanghai, China |
Product Categories |
Pharmaceutical Intermediates |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | Colorless Transparent Liquid | Colorless Transparent Liquid |
Water by Karl Fischer | <0.20% | 0.10% |
Density (20℃) | 0.942~0.967 | 0.942 |
Refractive Index n20/D | 1.434~1.438 | 1.435 |
Stabilizer | Stabilized with Diisopropylethylamine | <0.10% |
SEM-Cl Purity | >95.0% (GC) | 96.4% |
Infrared Spectrum | Consistent with Structure | Complies |
Conclusion | The product has been tested and complies with the given specifications |
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols C - Corrosive
Risk Codes R10 - Flammable
R34 - Causes burns
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28 - After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S16 - Keep away from sources of ignition.
UN IDs UN 2920 8/PG 2
WGK Germany 3
FLUKA BRAND F CODES 8-10-21
TSCA No
HS Code 2931900090
Hazard Class 3.2
Packing Group III
2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl) (CAS: 76513-69-4) is an organosilicon compound that is used as a reagent in organic synthesis. SEM-Cl is used in a variety of applications, including the synthesis of polymers, pharmaceuticals, agrochemicals, pesticides, heterocycles, and other organosilicon compounds.
SEM-Cl is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.
SEM-Cl is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent. SEM-Cl offers a versatile tool for selectively modifying specific functional groups.
SEM-Cl has been used in the synthesis of a variety of drugs, including antiretroviral drugs, anti-inflammatory drugs, and antiviral drugs.
In the synthesis of Ruxolitinib (CAS: 941678-49-5), SEM-Cl, as an important intermediate, plays an important role in the final quality and price of Ruxolitinib.
SEM-Cl, as a common silicone protective agent, but its price is expensive, not easy to preserve, purity is not high, has always been the concern of producers and users, is an urgent problem to be solved.