8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline CAS 100331-89-3 Indacaterol Maleate Intermediate Factory

Short Description:

8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline

CAS: 100331-89-3

Appearance: Off-White to Yellow Powder

Purity: >95.0% (HPLC)

Intermediate of Indacaterol Maleate (CAS: 753498-25-8)

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Commercial Supply Indacaterol Maleate (CAS: 753498-25-8) Related Intermediates:
5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride CAS: 312753-53-0
8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline CAS: 100331-89-3
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone CAS: 173140-90-4

Chemical Properties:

Chemical Name	8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline
Synonyms	8-(Benzyloxy)-5-(2-Bromoacetyl)quinolin-2(1H)-one; 5-(Bromoacetyl)-8-(Phenylmethoxy)-2(1H)-Quinolinone; 5-(2-Bromo-1-Oxoethyl)-8-Benzyloxy-2(1H)-Quinolinone; 5-Bromoacetyl-8-Benzyloxycarbostyril
CAS Number	100331-89-3
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C18H14BrNO3
Molecular Weight	372.21
Melting Point	192.0~194.0℃
Boiling Point	602.6±55.0℃ at 760 mmHg
Density	1.479±0.06 g/cm3
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Off-White to Yellow Powder
Purity / Analysis Method	>95.0% (HPLC)
Moisture (K.F)	<1.00%
Residue on ignition	<0.50%
Impurity A	<3.00% (5-Acetyl-8-(Benzyloxy)quinolin-2(1H)-one)
Any Other Single Impurity	<1.50%
Total Impurities	<5.00%
Infrared Spectrum	Conforms to Structure
Test Standard	Enterprise Standard
Usage	Indacaterol Maleate (CAS: 753498-25-8) Intermediate

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

FAQ:

100331-89-3 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline (CAS: 100331-89-3) with high quality, it is an intermediate typically in the synthesis of Indacaterol Maleate (CAS: 753498-25-8).

Indacaterol Maleate (CAS: 753498-25-8) is a new, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist and bronchodilator. It is used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. The European Medicines Agency (EMA) approved indacaterol as a drug in 2009 under the Onbrez trade name while in the United States the Food and Drug Administration approved it under the trade name Arcapta in 2011. The drug is manufactured as its maleate salt form. Also, indacaterol is a chiral molecule; however, only the pure R-enantiomer is distributed.