Ac-HMBA-Linker CAS 15561-46-3 4-(Acetoxymethyl)benzoic Acid Purity >98.0% (HPLC)

Short Description:

4-(Acetoxymethyl)benzoic Acid

Synonyms: Ac-HMBA-Linker

CAS: 15561-46-3

Purity: >98.0% (HPLC)

Appearance: White to Off-White Powder

Linkers for Solid Phase Synthesis

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-(Acetoxymethyl)benzoic Acid (Ac-HMBA-Linker) (CAS: 15561-46-3) with high quality. Ruifu Chemical supplys a series of linkers for solid phase synthesis. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Ac-HMBA-Linker, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	4-(Acetoxymethyl)benzoic Acid
Synonyms	Ac-HMBA-Linker; 4-[(Acetyloxy)methyl]benzoic Acid; 4-Acetoxymethylbenzoic Acid
Stock Status	In Stock
CAS Number	15561-46-3
Molecular Formula	C10H10O4
Molecular Weight	194.18 g/mol
Melting Point	123.0~124.0℃
Density	1.254±0.06 g/cm3
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Linkers for Solid Phase Synthesis
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White to Off-White Powder	Complies
Purity / Analysis Method	>98.0% (HPLC)	99.59%
1 H NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested & complies with the specifications

Package/Storage/Shipping:

Package: Fluoride bottle, glass bottle, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

4-(Acetoxymethyl)benzoic Acid (Ac-HMBA-Linker) (CAS: 15561-46-3), linkers for solid phase synthesis. A base labile 4-hydroxymethylbenzoic acid (HMBA) linker,it was effectively removed at pH=10. The HMBA linker was demonstrated to be stable to the conditions required for native chemical ligation, subsequent transformations and final purification. The benzyl ester, which forms the HMBA linker with the first amino acid, is stable to piperidine, used for Fmoc group removal, making the linkage applicable for chemical elongation of a peptide sequence with Fmoc strategies. A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. 4-hydroxymethylbenzoic acid linkage, which was cleaved by ammonolysis in isopropanol, gave the model peptide 1 in good overall yield (53% including functionalization).