S-Adenosyl-L-Methionine (Ademetionine; SAMe) CAS 29908-03-0
Ruifu Chemical is the leading manufacturer of S-Adenosyl-L-Methionine (Ademetionine; SAMe) (CAS: 29908-03-0) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase S-Adenosyl-L-Methionine, Please contact: alvin@ruifuchem.com
| Chemical Name | S-Adenosyl-L-Methionine |
| Synonyms | Ademetionine; S-Adenosylmethionine; SAMe; SAM; AdoMet |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 29908-03-0 |
| Molecular Formula | C15H22N6O5S |
| Molecular Weight | 398.44 g/mol |
| Melting Point | 267.0~269.0℃ |
| Sensitive | Very Hygroscopic |
| Water Solubility | Soluble in Water |
| Odor & Taste | Characteristics |
| COA & MSDS | Available |
| Sample | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Almost White Fine Powder (Very Hygroscopic) | Confirmed |
| Solubility | Soluble in Water | |
| Identification | 1. Chemical reaction | Positive reaction |
| 2. IR: Consistent with the spectrum obtained with RS | Confirmed | |
| 3. The retention time of a major peak meets requests | Confirmed | |
| Acid Value | 1.5~2.5 | 1.9 |
| Clarity and Color of Solution | Not More Intensely Colored Than RS Y1 | Confirmed |
| Water by Karl Fischer | ≤3.00% | 2.2% |
| Residue on Ignition | ≤0.30% | 0.14% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Endotoxin | ≤0.3EU/mg | Confirmed |
| Microbiological | Should Meet the Requirement | |
| Total Plate Count | ≤1000cfu/g | 55cfu/g |
| Yeast & Mold | ≤100cfu/g | 12cfu/g |
| E. Coli | Absent/10g | Complies |
| S. Aureus | Absent/10g | Complies |
| Salmonella | Absent/10g | Complies |
| S-Adenosyl-L-Homocystein | ≤0.50% | 0.10% |
| Methithioadenosine | ≤1.00% | 0.24% |
| Adenine | ≤0.50% | 0.09% |
| Related Substances | ||
| The Other Largest Impurities | ≤0.20% | 0.01% |
| The Other Total Impurities | ≤0.50% | 0.006% |
| (S,S) Isomer | >62.0% | 79.4% |
| Butanedisulfonate | 46.0~49.0% (Base on Dried) | 47.5% |
| Ademetionine | 50.0~53.0% (Base on Dried) | 52.1% |
| Total Content | >97.5% (Base on Dried) | 99.6% |
| Conclusion | The product has been tested and complies with the given specifications | |
| Shelf Life | 2 Years When Properly Stored | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R49 - May cause cancer by inhalation
R23 - Toxic by inhalation
R34 - Causes burns
Safety Description S53 - Avoid exposure - obtain special instructions before use.
S23 - Do not breathe vapour.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
HS Code 2934999099
S-Adenosyl-L-Methionine (Ademetionine; SAMe) (CAS: 29908-03-0) is a common cosubstrate involved in methyl group transfers. SAMe was first discovered in Italy by G. L. Cantoni in 1952, SAMe is a molecule produced constantly by all living cells,can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis,SAMe is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday SAMe is commonly used in pharmaceuticals, health care food industry both at domestic and international market. SAMe is sold in the United States as a dietary supplement.
1. S-Adenosyl-L-Methionine is a good nutrient for the liver, which can prevent alcohol, drugs and liver cell damage;
2. S-Adenosyl-L-Methionine has a significant preventive effect on chronic active hepatitis and other factors that cause liver damage, heart disease, cancer and so on.
3. S-Adenosyl-L-Methionine has been found to be as effective as drugs for treating arthritis and major depression.
4. In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some studies have shown that taking SAM regularly can help combat depression, liver disease, and osteoarthritis pain. A number of clinical trials have shown that it is good for depression, certain liver diseases and osteoarthritis. All other signs have not been confirmed.
5. Clinically used to improve liver function. The combination with L-DOPA for the treatment of Parkinson's disease can improve the efficacy of L-dopa and reduce side effects. Local pain, temporary anxiety and insomnia at the injection site can be seen.
S-Adenosyl-L-Methionine (Ademetionine; SAMe) (CAS: 29908-03-0) also has good therapeutic effect on arthritis, fibrous muscle, migraine and other diseases, and has little side effect. As early as the 1970s, SAMe was used as a prescription drug for arthritis in Europe. In 1999, the US FDA approved SAMe as a health product and has become one of the best-selling nutrition products in the United States.
S-Adenosyl-L-Methionine is mainly prepared by chemical synthesis, fermentation and enzymatic transformation. The fermentation method is to add the precursor L-Methionine to the basic medium containing C and N sources, and a large amount of S-Adenosylmethionine can be obtained by culturing microbial cells. This is currently the main route for industrial production of S-Adenosylmethionine. Among them, the microorganisms used for fermentation can be obtained by screening or recombination construction methods, which are recorded in many articles and patents at home and abroad. Some studies have provided a preparation method of S-adenosylmethionine, using polyhydroxy organic reagents to protect the activity of the enzyme, using adenosine triphosphate precursor, L-Methionine and phosphate ions as substrates, glucose or/and maltose as energy donors, adding a composition of metal ions, and using a permeable production strain to catalyze the production of S-Adenosylmethionine in whole cells. Using the composition of metal ions to regulate the metabolic flow to improve the energy self-coupling efficiency, adding organic reagents to protect the activity of the bacteria and enzymes, using a permeable production strain to prepare S-Adenosylmethionine, shorten the synthesis time, and make the product accumulate outside the cell, which can save the cost of subsequent separation and simplify the operation steps.
Information on the long-term safety of S-Adenosyl-L-Methionine is limited because the participants in most studies took it only for short periods of time. However, in one study of alcohol-related liver disease, participants took S-Adenosyl-L-methionine for 2 years; in that study, no serious side effects were reported.
People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAMe for their depressive symptoms except under the supervision of a health care provider because SAMe may worsen symptoms of mania.
Although S-Adenosyl-L-Methionine has been used to treat cholestasis during pregnancy, its safety during pregnancy has not been established.
SAMe may decrease the effects of levodopa (L-dopa), a drug used to treat Parkinson’s disease. It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.
There’s a theoretical concern about the use of SAMe by people who are immunocompromised (such as those who are HIV-positive). Immunocompromised people are at risk for Pneumocystis carinii infection, and SAMe enhances the growth of this microorganism.
Side effects of SAMe are uncommon, and when they do occur they are usually minor problems such as nausea or digestive upsets.
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