AM-095 CAS 1345614-59-6 Purity ≥98.0% (HPLC) e.e. ≥98.0% LPA1 Receptor Antagonist
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of AM-095 (CAS: 1345614-59-6) with high quality. AM095 is a potent LPA 1 receptor antagonist. Ruifu Chemical has been supplying pharmaceutical intermediates and APIs more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase AM-095 or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | AM-095 |
| Synonyms | AM095; AM 095; AM-095 Sodium Salt; AM095 Sodium; AM-095 Sodium; 4'-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid sodium salt (1:1); Sodium (R)-2-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetate |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 1345614-59-6 |
| Molecular Formula | C27H25N2NaO5 |
| Molecular Weight | 480.5 g/mol |
| Store Under Inert Gas | Store Under Inert Gas |
| Solubility | Soluble in DMSO; Insoluble in H2O |
| Storage Temperature | Store Long-Term Lyophilized at -20℃, Keep Desiccated |
| Shipping Condition | Shipped Under Ambient Temperature for Short Term |
| Expiration Date | In Lyophilized Form, AM-095 is Stable for 24 Months |
| Attention | Aliquot to Avoid Multiple Freeze/Thaw Cycles to Prevent Loss of Potency |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
Inhibitor |
| Target | Potent LPA1 Receptor Antagonist |
| Caution | Not For Human Use. For Research Use Only. Do Not Sell to Patients |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Light Yellow to Yellow Solid | Conforms |
| Identification A | HNMR Spectrum of Sample Corresponds to that of Standard Preparation |
Conforms |
| Identification B | Mass Spectrum of Sample Corresponds to that of Standard Preparation |
Conforms |
| Identification C | The Retention Time of the Major Peak in the Chromatogram of Sample Corresponds to that in the Chromatogram of Standard Preparation |
Conforms |
| Purity / Analysis Method | ≥98.0% (HPLC) | 98.31% |
| Enantiometric Excess . | ≥98.0% (by HM-274B_4) | 99.57% |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients. For research use only.
None of the products will be supplied to countries in which this could be in conflict with the existing patents.
Package: Bottle, Aluminium foil bag, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store at -20℃, sealed in dry place. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
AM-095 (CAS: 1345614-59-6) is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 μM for mouse or recombinant human LPA1, respectively.
In vitro, AM-095 has shown to inhibit LPA1-induced chemotaxis of both mouse LPA1/CHO cells and human A2058 melanoma cells with IC50 values of 0.78 μM and 0.23μM.
In vivo, AM-095 could dose-dependently block LPA-induced histamine release with an ED50 value of 8.3 mg/kg in mice. Additionally, AM-095 has been revealed to remarkably reduce the BALF collagen and protein with an ED50 value of 10 mg/kg in lungs. AM-095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice.
