Argatroban CAS 74863-84-6 API Factory High Purity Anticoagulant
Manufacturer Supply Argatroban Related Intermediates:
Ethyl (2R,4R)-4-Methyl-2-Piperidinecarboxylate CAS 74892-82-3
N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester CAS 74874-09-2
3-Methyl-8-Quinolinesulphonyl Chloride CAS 74863-82-4
Argatroban Monohydrate CAS 141396-28-3
Argatroban Anhydrous CAS 74863-84-6
| Chemical Name | Argatroban |
| Synonyms | Argatroban Anhydrous |
| CAS Number | 74863-84-6 |
| CAT Number | RF-API67 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C23H36N6O5S |
| Molecular Weight | 508.63 |
| Melting Point | 188.0~189.0℃ |
| Boiling Point | 801.3ºC at 760 mmHg |
| Density | 1.47 g/cm3 |
| Shipping Condition | Shipped Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystalline Powder |
| Identification HPLC | The retention time of principle peak obtained from Test solution conform with that obtained from Standard solution, as test in Assay |
| Identification IR | Conforms to the IR Spectrum of AG RS |
| Identification UV | In the 259nm and 332nm wavelength place should have maximum absorption |
| Water | 2.5-4.5% |
| Solution Color & Clarity | Solution Should be Clear Colorles |
| Relate Substances | |
| Impurity A + Impurity H | ≤0.10% |
| Impurity B | ≤0.10% |
| Impurity C + Impurity E | ≤0.10% |
| Impurity D | ≤0.10% |
| Impurity I | ≤0.10% |
| Bach of Unspecified Impurity | ≤0.10% |
| Total Impurities | ≤0.30% |
| Residual Solvents | |
| Methanol | ≤3000ppm |
| Ethanol | ≤5000ppm |
| Dichloromethane | ≤600ppm |
| Ethyl Acetate | ≤5000ppm |
| Enantiomer (HPLC) | ≤0.10% |
| Isomer Ratio (HPLC) | 30.0%-40.0% |
| Chloride | ≤0.01% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals | ≤10ppm |
| Bacterial Endotoxins | <5EU/mg |
| Microbial Limit | TAMC ≤1000 cfu/g |
| Assay | 98.0%-102.0% (on anhydrous basis) |
| Test Standard | Enterprise Standard |
| Usage | API, Synthetic Antithrombotic Agent Anticoagulant |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Argatroban (CAS: 74863-84-6) with high quality, API.
Argatroban (CAS: 74863-84-6) is a new synthetic antithrombotic agent useful in maintenance anticoagulation them ischemic stroke and disseminated intravascular coagulation. It is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy.
