Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV HIV-1 Protease Inhibitor
Supply with High Purity and Stable Quality
Chemical Name: Atazanavir
CAS: 198904-31-3
HIV-1 Protease Inhibitor
API High Quality, Commercial Production
Chemical Name | Atazanavir |
Synonyms | BMS-232632 |
CAS Number | 198904-31-3 |
CAT Number | RF-API70 |
Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
Molecular Formula | C38H52N6O7 |
Molecular Weight | 704.86 |
Melting Point | 207.0~209.0℃ |
Solubility | Soluble in DMSO; Insoluble in Water |
Long-Term Storage | Store Long-term at -20℃ |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | White Powder |
Form | Free Base |
Loss on Drying | ≤0.50% |
Residue on Ignition | ≤0.20% |
Heavy Metals | ≤20ppm |
Impurity A | ≤0.10% |
Impurity B | ≤0.10% |
Single Impurity | ≤0.20% |
Total Impurities | ≤1.0% |
Purity/Analysis Method | ≥99.0% (HPLC) |
pH | 5.0~8.0 |
Test Standard | Enterprise Standard |
Usage | HIV-1 Protease Inhibitor Anti-HIV |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
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Atazanavir (CAS 198904-31-3) is an antiretroviral, novel and potent azapeptide drug of the protease inhibitor (PI) class. It is sold under the trade name Reyataz. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including Indinavir, Nelfinavir, Ritonavir, Saquinavir and Amprenavir. Atazanavir is distinguished from other PIs in that it can be given once-daily and has lesser effects on the patient's lipid profile. Like other protease inhibitors, it is used only in combination with other HIV medications. Atazanavir is a novel azapeptide HIV protease inhibitor. Antiviral. It is taken by mouth once a day.
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