Baricitinib CAS 1187594-09-7 Assay 98.0%~102.0% Rheumatoid Arthritis

Short Description:

Chemical Name: Baricitinib

Synonyms: INCB 028050; LY3009104

CAS: 1187594-09-7

Assay (Anhydrous Basis): 98.0%~102.0% (HPLC)

Appearance: White to Off-White Powder

Used for the treatment of Rheumatoid Arthritis

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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1187594-09-7 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Baricitinib (CAS: 1187594-09-7) with high and stable quality control, used for the treatment of rheumatoid arthritis (RA).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available.
Purchase Baricitinib and Baricitinib intermediates, Please contact us by e-mail: alvin@ruifuchem.com for quotation requests. Please provide quantity, purity, and any other specific requirements.

Intermediates of Baricitinib (CAS: 1187594-09-7):

Baricitinib API	CAS 1187594-09-7
1-Boc-3-Azetidinone	CAS 398489-26-4
3-Hydroxyazetidine Hydrochloride	CAS 18621-18-6
1-Boc-3-(Cyanomethylene)azetidine	CAS 1153949-11-1
2-[1-(Ethylsulfonyl)azetidin-3-ylidene]acetonitrile	CAS 1187595-85-2
2-(Azetidin-3-ylidene)acetonitrile Hydrochloride	CAS 1314910-43-4
1-(1-Ethoxyethyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester	CAS 1029716-44-6
4-(1H-Pyrazol-4-yl)-7-[[2-(Trimethylsilyl)ethoxy]methyl]-7H-Pyrrolo[2,3-d]pyrimidine	CAS 941685-27-4

1187594-09-7 - Chemical Properties:

Chemical Name	Baricitinib
Synonyms	INCB 028050; LY3009104; 1-(Ethylsulfonyl)-3-[4-(7H-Pyrrolo[2,3-d]pyriMidin-4-yl)-1H-Pyrazol-1-yl]-3-Azetidineacetonitrile; 2-[1-Ethylsulfonyl-3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile; 2-(3-(4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-1H-Pyrazol-1-yl)-1-(Ethylsulfonyl)azetidin-3-yl)acetonitrile
Stock Status	In Stock
CAS Number	1187594-09-7
Molecular Formula	C16H17N7O2S
Molecular Weight	371.42 g/mol
Melting Point	212.0~215.0℃
Density	1.56
Solubility	Soluble in DMSO, Insoluble in Water
Storage Temp.	-20℃
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	API (Active Pharmaceutical Ingredient)
Caution	Not for Human or Diagnostics or Therapeutics Use. For Research Use Only.
Brand	Ruifu Chemical

1187594-09-7 - Specifications:

Items	Specifications	Results
Appearance	White to Off-White Powder	White Powder
Identification	By IR and By HPLC	Complies
Clarity Of Solution	Conform to Standard	Complies
Melting Point	212.0~215.0℃	213.1~214.0℃
Water by Karl Fischer	<0.50%	0.08%
Residue on Ignition	<0.20%	0.07%
Heavy Metals (Pb)	<20ppm	<10ppm
Relative Substances
Any Single Impurity	<0.10%	0.07%
Total Impurities	<1.00%	0.18%
Assay / Analysis Method	98.0%~102.0% (on the Anhydrous Basis)	99.90%
Conclusion	The product has been tested and complies with the given specifications

1187594-09-7 - Attention:

If you are interested in our products or have any questions, please feel free to contact us!
Field Of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

1187594-09-7 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (-20℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

1187594-09-7 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

1187594-09-7 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

1187594-09-7 - Safety Information:

HS Code 2934999099

1187594-09-7 - Application:

Baricitinib (CAS: 1187594-09-7), (trade name Olumiant), is a drug for the treatment of rheumatoid arthritis (RA), being developed by Incyte and Eli Lilly.It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved in Europe. Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis. Baricitinib is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs as monotherapy or in combination with methotrexate.