Bicalutamide CAS 90357-06-5 API Factory High Quality Advanced Prostate Cancer

Short Description:

Name: Bicalutamide

CAS: 90357-06-5

Appearance: White to Off-White Crystalline Powder

Assay: 98.0%~102.0%

Bicalutamide in the treatment of Advanced Prostate Cancer

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Description:

Manufacturer Supply with High Purity and Stable Quality
Name: Bicalutamide
CAS: 90357-06-5  
Bicalutamide in the treatment of Advanced Prostate Cancer
API High Quality, Commercial Production 

Chemical Properties:

Name Bicalutamide
Synonyms N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionamide
CAS Number 90357-06-5
CAT Number RF-API76
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C18H14F4N2O4S
Molecular Weight 430.37
Storage Temperature 2-8℃
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Off-White Crystalline Powder
Identification A IR: Spectrum of the sample corresponds to that of reference standard
Identification B HPLC: The retention time of the major peak of the sample solution corresponds to that of the standard solution
Identification C Organic Fluoride Identification
Solubility  Freely Soluble in Acetone and Tetrahydrofuran, Slightly Soluble in Ethyl Acetate
Melting Point 191.0~195.0℃
Water Content (by K.F) ≤0.20% 
Fluoride Content 15.9%~18.5%
Loss on Drying ≤0.50% 
Residue on Ignition ≤0.10% 
Heavy Metals ≤10ppm
Residual Solvents
Tetrahydrofuran ≤0.072% 
Toluene ≤0.089% 
N-Hexane ≤0.029% 
Acetone ≤0.50% 
Ethyl Acetate ≤0.50% 
Related Substances  
N,N’-Dimethyl Acetamide ≤0.109%
Bicalutamide Aminobenzonitrile ≤0.10%
Bicalutamide Related Compound A Isomer A ≤0.10%
Bicalutamide Related Compound A Isomer B ≤0.10%
Desfluoro Bicalutamide ≤0.20%
2-Fluoro Bicalutamide ≤0.20%
Deoxy Bicalutamide  ≤0.20%
Bicalutamide Sulfide ≤0.10%
Any Unspecified Impurity ≤0.10%
Total Impurities ≤0.50%
Particle Size 90%<10um; 50%<5um
Assay 98.0%~102.0% (on the dried basis)
Microbiological Tests
Total Viable Aerobic Count ≤500CFU/g
Yeasts and Molds ≤50CFU/g
Shelf Life 24 Months
Test Standard Enterprise Standard; USP Standard
Usage API, in the treatment of Advanced Prostate Cancer

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

Bicalutamide (CAS: 90357-06-5) is a non-steroidal androgen antagonist, which competes androgen receptor with the androgen, blocks cellular uptake of androgen, and inhibits the binding of androgens to the target organ. It binds with the androgen receptor that forms receptor complex, which enters the nucleus and combined with the nucleoprotein, consequently inhibiting tumor cell growth. It can be as a first-line drug for palliative treatment of advanced prostate cancer. Bicalutamide was launched in the United Kingdom, its first worldwide market, for the treatment of advanced prostate cancer in combination with an LHRH analog or surgical castration. A non-steroidal, peripherally selective antiandrogen, bicalutamide inhibits the action of dihydrotestosterone and testosterone at target sites by competitive binding to the cytosolic androgen receptor. It was reportedly well tolerated with no significant cardiovascular and metabolic side effects due to the benefit of lacking any steroid activity. The efficacy of bicalutamide as a monotherapy has been demonstrated clinically. Promising response rates were also reported in treating colorectal, breast, pancreas and non-small cell lung cancers.

  • Write your message here and send it to us