Big discounting Methyl 2-Hydroxy-3-Methoxy-3 3-Diphenylpropanoate - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate Purity ≥99.0% (HPLC) Factory – Ruifu

Commercial Supply Bedaquiline Related Intermediates:
3-Benzyl-6-Bbromo-2-Mmethoxyquinoline CAS: 654655-69-3
3-Benzyl-6-Bromo-2-Chloroquinoline CAS: 654655-68-2
3-(Dimethylamino)-1-(Naphthalen-1-yl)propan-1-one Hydrochloride CAS: 5409-58-5  
Bedaquiline Fumarate CAS: 845533-86-0

3-Benzyl-6-bromo-2-chloroquinoline (CAS: 654655-68-2) is a main intermediate of Bedaquiline Fumarate (CAS: 845533-86-0). Bedaquiline Fumarate is a diarylquinone drug developed by Janssen Pharmaceutical. The drug, which was approved in 2012 for the treatment of multidrug-resistant tuberculosis (MDR-TB), was developed in partnership with Johnson & Johnson and represents the first new tuberculosis therapy approved in over four decades. Bedaquiline Fumarate used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of th mycobacteria.