Boc Anhydride (Boc)2O CAS 24424-99-5 Di-tert-Butyl Dicarbonate Purity >99.5% (GC) Factory

Di-tert-Butyl Dicarbonate (Boc Anhydride; (Boc)2O) (CAS: 24424-99-5) is a widely used reagent for introducing protecting groups in peptide synthesis. It serves as a protecting group used in solid phase peptide synthesis.
Di-tert-Butyl Dicarbonate is an acyclic carboxylic anhydride. It is functionally related to a dicarbonic acid.
(Boc)2O is a reagent mainly used for the introduction of the Boc protecting group to amine functionalities. It is also used as a dehydrating agent in some organic reactions, particularly with carboxylic acids, certain hydroxyl groups, or with primary nitroalkanes. Reagent for the preparation of Boc protected amines.
(Boc)2O is especially used in amino acid protection. Used as an intermediate in medicine and organic synthesis, it is an important amino protective agent used in the synthesis of medicine and agrochemical products
Production method Potassium tert-butoxide is dissolved in anhydrous tetrahydrofuran, and dry carbon dioxide is introduced at -5 ~-20℃ to generate a slurry, continue to maintain a low temperature, and add phosgene benzene solution dropwise to prepare tert-butyl tricarbonate. Dissolve it in carbon tetrachloride, add an appropriate amount of 1,4-diazabicyclo [2,2] octane, stir at 25 ℃ to completely release carbon dioxide and convert it into ditert-butyl dicarbonate.
Hazard An irritant that may cause serious eye injury; May cause skin sensitization; Highly toxic by inhalation
Flammability and Explosibility Flammable