Boc-D-Trp-OH CAS 5241-64-5 Purity >98.5% (HPLC) Factory

N-Boc-D-Tryptophan (Boc-D-Trp-OH) (CAS: 5241-64-5), amino acids and derivatives, peptide synthesis, organic synthesis intermediate, pharmaceutical intermediates, biochemical reagents. 
Boc-D-Trp-OH is an N-Boc-protected form of D-Tryptophan. D-Tryptophan is an unnatural isomer of L-Tryptophan and is classified as an essential amino acid. D-Tryptophan has been synthesized as part of some potent Oxytocin antagonists that treat preterm labour.
Brief introduction: Boc-D-Tryptophan can be used as an intermediate in pharmaceutical synthesis, such as tadalafil (tadalafil). tadalafil is developed by Lilly pharmaceutical company in the United States. it relies on PDE-5 to improve the vasodilation effect of NO by inhibiting the decomposition of cGMP, so that ED patients can regain the ability of penile erection, and is mainly used to treat male erectile dysfunction. It was listed in Europe in February 2003 and in the United States in December 2003. It is the third new drug approved by FDA for ED.
Preparation: compound D-Tryptophan (50g, 0.245mol) is weighed in a three-mouth bottle, mechanically stirred, 500ml of water and Triethylamine (74g, 0.731mol),(Boc)2O (56g, 0.257mol) are added. The reaction was stirred at 45 degrees Celsius for 12 hours. At the end of the reaction, 0.1% phosphoric acid solution is added dropwise, a large amount of solid is generated, the PH value is adjusted to 7, and then post-treatment is carried out. Filtration, the resulting solid is dissolved with ethyl acetate, the resulting solution is washed once with water, anhydrous sodium sulfate is dried, and after filtration, the organic phase is spin-dried to prepare the compound Boc-D-Tryptophan in an amount of 70.9g (0.233mol), and the yield of Boc-D-Tryptophan is calculated to be 95.1%.