Boc-L-Lysine CAS 13734-28-6 (Boc-Lys-OH) Purity >98.0% (HPLC) Factory

Boc-L-Lysine (Boc-Lys-OH) (CAS: 13734-28-6), amino acids and derivatives, peptide synthesis, organic synthesis intermediate, pharmaceutical intermediates, biochemical reagents. Boc-L-Lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. Boc-L-Lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to the ir respective amino acids via cleavage of the urethane bond. Boc-Lys-OH can be used as a building block to synthesize: • A heterotrifunctional peptide-based linker molecule applicable as a bio-labeling reagent. • Lysine derivatives of azamacrocycle and anthraquinone. • Boc-Lys(Bn4-DTPA)-OH, a precursor to synthesize diethylene triamine pentaacetic acid (DTPA) containing peptides. • A ferrocene-amino acid conjugate which is used in developing chemical warfare agent (CWA) senso. 

Preparation 1.0g Lysine, 7.5g di-tert-Butyl Dicarbonate (Boc-Anhydride), 1.1g potassium hydroxide and not less than 20g ethanol were added to a 50ml round bottom flask, and stirred for 3 hours at 25-30℃ on a magnetic stirrer. Ethanol was removed from a rotary evaporator, 20g of ethyl acetate was added, 20g of water was washed three times, the upper organic layer was dried with sodium sulfate, then stirred and crystallified at 1-10℃ for 15 hours, filtered and dried to obtain 1.54g of white solid, which was ditert-butoxycarbonyllysine, and its molar yield was 65.0% (based on Lysine).