Brimonidine Tartrate CAS 70359-46-5 Assay 99.0%~101.0%

Short Description:

Chemical Name: Brimonidine Tartrate 

CAS: 70359-46-5

Assay: 99.0%~101.0% (on Dried Basis)

White or Slightly Yellowish or Slightly Brownish Powder

A Highly Selective α-Adrenergic Receptor Agonist

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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70359-46-5 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Brimonidine Tartrate (CAS: 70359-46-5) with high quality. Selective α2-adrenergic receptor agonist, a drug used to treat open-angle glaucoma or ocular hypertension. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Brimonidine Tartrate, Please contact: alvin@ruifuchem.com

70359-46-5 - Chemical Properties:

Chemical Name Brimonidine Tartrate 
Synonyms Brimonidine L-Tartrate; UK 14304 Tartrate; AGN190342 Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine (2R,3R)-2,3-Dihydroxysuccinate
Stock Status In Stock, Commercial Production  
CAS Number 70359-46-5
Molecular Formula C11H10BrN5·C4H6O6
Molecular Weight 442.23 g/mol
Melting Point 207.0~208.0℃(dec.) 
Sensitive Air Sensitive, Heat Sensitive   
COA & MSDS Available
Origin Shanghai, China
Shelf Life 24 Months if Stored Properly 
Category   API (Active Pharmaceutical Ingredient)   
Brand Ruifu Chemical

70359-46-5 - Specifications:

Items Specifications  Results
Appearance White or Slightly Yellowish or
Slightly Brownish Powder 
Conforms  
Identification A Specific Optical Rotation Conforms
Identification B Infrared Absorption Spectrophotometry Conforms
Solubility Soluble in water, practically insoluble in anhydrous ethanol and in toluene Conforms
Specific Optical Rotation +9.0° ~ +10.5° +9.6°
Loss on Drying ≤0.50% 0.20%
Sulfated Ash ≤0.20% 0.07%
Heavy Metals ≤20ppm <20ppm 
Related Substances    
Specified Impurities    
N-(imidazolidin2ylidene)quinoxalin-6-amine  ≤0.10% Conforms
5-bromoqulinoxalin-6-amine ≤0.10% Conforms
Quinoxalin-6-amine ≤0.10% Conforms
1-(5-bromoquinoxalin-6-yl)thiourea ≤0.10% Conforms
2-(5-bromoquinoxalin-6-yl)guanidine ≤0.10% Conforms
5-bromo-N-(1H-imidazol-2-yl)Quinoxalin-6-amine ≤0.10% Conforms
1-(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl)urea ≤0.10% Conforms
Unspecified Impurities ≤0.10% Conforms
Total ≤0.20% 0.12%
Assay 99.0%~101.0%(on Dried Basis) 99.8%
Conclusion This product by inspection accords with the BP2015 Standard 

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Avoid exposure to direct sunlight, moisture and excessive heat.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

70359-46-5 - Safety & Regulations :

Hazard Statements H301: Toxic if swallowed.
Precautionary Statements
P501: Dispose of contents/ container to an approved waste disposal plant.
P270: Do not eat, drink or smoke when using this product.
P264: Wash skin thoroughly after handling.
P301 + P310 + P330: IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405: Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.29.9000

70359-46-5 - Application:

Brimonidine Tartrate (CAS: 70359-46-5) is a highly selective α2-receptor blocker, successfully developed by the US Company Allergan, which is an eye medication. It can reduce intraocular pressure (IOP). Brimonidine Tartrate ophthalmic solution saling in the market is Brimonidine Tartrate form, which is a good IOP-lowering medication for chronic open-angle glaucoma and ocular hypertension treatment of patients, but also for argon laser IOP levels. Brimonidine Tartrate ophthalmic solution has a dual mechanism of action by reducing aqueous humor production and increasing the pigment layer of liquid scleral outflow therapeutic purposes. After dropping into the eye, the effect is rapid, and it can reach the peak when using up to 2h, and the effective time can maintain 12h. Blood can only detect traces of drugs. This product has first-pass metabolism in the liver, and metabolites excreted in the urine by the kidneys. Systemic absorption and distribution are not affected, and the elderly do not need dose adjustment. Brimonidine Tartrate ophthalmic solution compared with other α-blockers, the fat-soluble is small, while it does not easy to pass through blood-brain barrier and does not produce sedation, hypotension and other similar clonidine central adverse reactions. Brimonidine Tartrate Ophthalmic Solution is highly selective for α2-adrenergic receptors, and α2/α1 ratio of receptor affinity is more than 1000 times. The effect of alpha 2 receptors can lead to lower intraocular pressure. And the role of the alpha 1 receptors can lead to vascular contraction, eyelid retraction or reduction and dilation of the pupil. Long term application of this product will not cause rapid desensitization. In addition, compared with β-blockers, Brimonidine Tartrate eye drops for minor cardiovascular effects, it has no effect on lung function, so it is suitable for disabled patients β-blockers. Furthermore, when used alone β-blocker, it can not achieve therapeutic purposes, and you can simultaneously increase the FDA.  

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