Candesartan Cilexetil CAS 145040-37-5 Purity >99.0% (HPLC) API Factory

Short Description:

Chemical Name: Candesartan Cilexetil

CAS: 145040-37-5

Purity: >99.0% (HPLC)

Appearance: White to Off-White Crystalline Powder

A Selective Angiotensin II Receptor Antagonist

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

Send email to us

Product Detail

Product Tags

Description:

Ruifu Chemical Supply Candesartan Cilexetil Intermediate With High Purity
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Trityl Candesartan Cilexetil CAS 170791-09-0

Chemical Properties:

Chemical Name	Candesartan Cilexetil
Synonyms	TCV-116; 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-Carboxylate
CAS Number	145040-37-5
CAT Number	RF-PI1891
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C33H34N6O6
Molecular Weight	610.66
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Identification HPLC	The retention time of the major peak in the chromatogram of the sample corresponds to that in the chromatogram obtained with the standard
Identification IR	IR infrared absorption spectrum is identical to that of Candesartan Cilexetil reference standard
Clarity and Color Solution	Solution in chloroform at 5% is clear and colourless
Purity / Analysis Method	>99.0% (HPLC)
Melting Point	155.0~160.0℃
Loss on Drying	<0.30%
Residue on Ignition	<0.10%
Heavy Metals	<10ppm
Arsenic (As)	<1ppm
Particle Size Distribution	90% <30 μm
Organic Impurities	by HPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Any Unknown Impurity	<0.15%
Total Impurities	<0.60%
Assay by Potentiometry	99.0~101.0% of C33H34N6O6, calculated on the anhydrous substance
Organic Volatile Impurity
Methano	<0.30%
Ethanol	<0.50%
Diethyl Ether	<0.50%
Aceton	<0.50%
Dichloromethan	<0.06%
Dimethylformamide	<0.088%
Microbiological Contarnination
Total Aerobic Microbial Count	<1000cfu/g
Moulds & Yeasts	<100cfu/g
E.Coli	Absent
Salmonella	Absent
Test Standard	Enterprise Standard
Usage	API; Antihypertensive Agent

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension. Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.