8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline CAS 100331-89-3 Indacaterol Maleate Intermediate Factory

Short Description:

8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline 

CAS: 100331-89-3

Appearance: Off-White to Yellow Powder

Purity: >95.0% (HPLC) 

Intermediate of Indacaterol Maleate (CAS: 753498-25-8) 

Contact: Dr. Alvin Huang 

Mobile/Wechat/WhatsApp: +86-15026746401 

E-Mail: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name 8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline
Synonyms 8-(Benzyloxy)-5-(2-Bromoacetyl)quinolin-2(1H)-one; 5-(Bromoacetyl)-8-(Phenylmethoxy)-2(1H)-Quinolinone; 5-(2-Bromo-1-Oxoethyl)-8-Benzyloxy-2(1H)-Quinolinone; 5-Bromoacetyl-8-Benzyloxycarbostyril
CAS Number 100331-89-3
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C18H14BrNO3
Molecular Weight 372.21
Melting Point 192.0~194.0℃
Boiling Point  602.6±55.0℃ at 760 mmHg 
Density   1.479±0.06 g/cm3 
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance Off-White to Yellow Powder
Purity / Analysis Method >95.0% (HPLC)
Moisture (K.F) <1.00%
Residue on ignition <0.50%
Impurity A <3.00% (5-Acetyl-8-(Benzyloxy)quinolin-2(1H)-one)
Any Other Single Impurity <1.50%
Total Impurities <5.00%
Infrared Spectrum Conforms to Structure
Test Standard Enterprise Standard
Usage Indacaterol Maleate (CAS: 753498-25-8) Intermediate 

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

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FAQ:

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100331-89-3 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline (CAS: 100331-89-3) with high quality, it is an intermediate typically in the synthesis of Indacaterol Maleate (CAS: 753498-25-8).

Indacaterol Maleate (CAS: 753498-25-8) is a new, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist and bronchodilator. It is used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. The European Medicines Agency (EMA) approved indacaterol as a drug in 2009 under the Onbrez trade name while in the United States the Food and Drug Administration approved it under the trade name Arcapta in 2011. The drug is manufactured as its maleate salt form. Also, indacaterol is a chiral molecule; however, only the pure R-enantiomer is distributed.  

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