(3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride CAS 1062580-52-2 Purity >99.0% (GC) Tofacitinib Citrate Intermediate
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride (CAS: 1062580-52-2) with high quality, intermediate of Tofacitinib Citrate (CAS: 540737-29-9). Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Tofacitinib Citrate Intermediates, please contact us by e-mail: alvin@ruifuchem.com
Chemical Name | (3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride |
Synonyms | cis-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride; (3R,4R)-cis-1-Benzyl-4-Methyl-3-(Methylamino)piperidine Dihydrochloride |
Stock Status | In Stock, Regular Stock Quantity 500kgs |
CAS Number | 1062580-52-2 |
CAS Free Base | 477600-70-7 |
Molecular Formula | C14H23ClN2 |
Molecular Weight | 254.8 g/mol |
Melting Point | 249.0~251.0℃ |
Store Under Inert Gas | Store Under Inert Gas (Nitrogen or Argon) at 2-8℃ |
Storage Temperature | Store Long-Term in a Cool and Dry Place |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Product Categories |
Pharmaceutical Intermediates |
Caution | Not For Human or Veterinary Use. For Research Use Only. |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | White Solid | White Solid |
Melting Point | 249.0~251.0℃ | 249.0~251.0℃ |
Water by Karl Fischer | <0.50% | 0.29% |
Purity / Analysis Method | >99.0% (by HPLC Area) | 99.9% |
Chiral Purity (e.e.%) | >99.0% (by HPLC) | 99.9% |
1H NMR Spectrum | Conforms to Structure | Conforms |
Mass Spectrum | Conforms to Structure | Conforms |
Conclusion | The product has been tested and complies with the given specifications | |
Application | Intermediate of Tofacitinib Citrate (CAS: 540737-29-9) |
Package: Fluorinated bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Class | IRRITANT |
HS Code | 2933322000 |
(3R,4R)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine Dihydrochloride (CAS: 1062580-52-2), intermediate of Tofacitinib Citrate (CAS: 540737-29-9). In November 2012, the US FDA approved Tofacitinib for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate. Tofacitinib is the first small molecule kinase inhibitor approved for the treatment of RA. Tofacitinib is an inhibitor of the four subtypes of Janus kinase (JAK): JAK1, JAK2, JAK3, and Tyk2. The JAKs are intracellular, nonreceptor tyrosine kinases that play important roles in the signal transduction pathway of many cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) and are involved in the propagation of inflammation in RA. Tofacitinib acts by inhibiting the phosphorylation and activation of signal transducers and activators of transcription (STATs), thereby suppressing the production of inflammatory mediators in joint tissue.
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