Apixaban Intermediate CAS 1267610-26-3 1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one Purity ≥99.0% (HPLC)

Short Description:

1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one

CAS: 1267610-26-3

Purity: ≥99.0% (HPLC)

Appearance: Off-White to Light Yellow Powder

Intermediate of Apixaban (CAS: 503612-47-3)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Ruifu Chemical is the leading manufacturer of 1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one (CAS: 1267610-26-3) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Apixaban intermediates, Please contact: alvin@ruifuchem.com

Apixaban Intermediates:

Chemical Properties:

Chemical Name 1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one 
Synonyms 1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Pyridinone; Apixaba Inretmediate A; Apixaban int. A; Apixaban Impurity S; Apixaban Impurity 47; Apixaban Related Impurities 2
Stock Status In Stock, Commercial Production
CAS Number 1267610-26-3
Molecular Formula C15H19N3O2
Molecular Weight 273.33 g/mol
Melting Point >246℃ 
Density 1.277±0.06 g/cm3 
COA & MSDS Available
Origin Shanghai, China
Category   Intermediate of Apixaban (CAS: 503612-47-3) 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance Off-White to Light Yellow Powder  Off-White Powder 
Purity / Analysis Method ≥99.0% (HPLC)  99.65% 
Max. Individual Impurity  ≤0.20% 0.12%
Loss on Drying ≤0.50% 0.3%
Infrared Spectrum Conforms to Structure Complies 
NMR Spectrum Conforms to Structure Complies
Conclusion The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

1267610-26-3 - Application:

1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one (CAS: 1267610-26-3) is an intermediate in the synthesis of Apixaban (CAS: 503612-47-3), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. Apixaban is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation. Eliquis (Apixaban), a direct inhibitor of factor Xa (FXa), was approved by the European Commission on May 18, 2011 for prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective hip or knee replacement surgery.

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