1-Chloro-2-Deoxy-3,5-Di-O-Toluoyl-L-Ribofuranose CAS 141846-57-3 Telbivudine Intermediate Assay >90.0% (AgNO3 Titration)
Ruifu Chemical is the leading manufacturer of 1-Chloro-2-Deoxy-3,5-Di-O-Toluoyl-L-Ribofuranose (CAS: 141846-57-3) with high quality, intermediate of Telbivudine (CAS: 3424-98-4). Telbivudine is a nucleoside analog that is widely used in the treatment of hepatitis B virus (HBV) infection. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service. Purchase our product, Please contact: alvin@ruifuchem.com
Chemical Name | 1-Chloro-2-Deoxy-3,5-Di-O-Toluoyl-L-Ribofuranose |
Synonyms | Telbivudine Impurity 6; (2S,3R,5R)-5-Chloro-2-(((4-Methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-Methylbenzoate; Alpha-L-Erythro-Pentofuranosyl Chloride-2-Deoxy-Bis(4-Methyl Benzoate) |
Stock Status | In Stock, Commercial Production |
CAS Number | 141846-57-3 |
Molecular Formula | C21H21ClO5 |
Molecular Weight | 388.84 g/mol |
Melting Point | 117.0~119.0℃ |
Density | 1.28±0.10 g/cm3 |
Storage Temp. | Store Long-Term in a Cool & Dry Place (2~8℃) |
Stability | Moisture Sensitive, Unstable in Solution |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | Creamish to Off-White Powder | Off-White Powder |
Loss on Drying | <1.00% | 0.79% |
Specific Optical Rotation | -115.0° ~ -128.0° | -117.2° |
Assay / Analysis Method | >90.0% (AgNO3 Titration) | 98.5% |
Conclusion | The product has been tested and complies with the given specifications | |
Application | Intermediate of Telbivudine (CAS: 3424-98-4) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
1-Chloro-2-Deoxy-3,5-Di-O-Toluoyl-L-Ribofuranose (CAS: 141846-57-3), intermediate of Telbivudine (CAS: 3424-98-4). Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance.
Telbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.
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