4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile CAS 143782-23-4 Enzalutamide Intermediate Purity >98.0% (GC)

Short Description:

4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile 

CAS: 143782-23-4

Purity: >98.0% (GC)

Appearance: Off-White Powder  

Intermediate of Enzalutamide (CAS: 915087-33-1)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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143782-23-4 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile (CAS: 143782-23-4) with high quality, intermediate of Enzalutamide (CAS: 915087-33-1). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Enzalutamide Intermediates, Please contact: alvin@ruifuchem.com

143782-23-4 - Chemical Properties:

Chemical Name 4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile 
Synonyms 4-Cyano-3-(Trifluoromethyl)phenyl Isothiocyanate; Isothiocyanic Acid 4-Cyano-3-(Trifluoromethyl)phenyl Ester; 4-Isothiocyanato-2-Trifluoromethylbenzonitrile; 3-Fluoro-4-Methylphenylisothiocyanate
Stock Status In Stock, Commercial Production  
CAS Number 143782-23-4
Molecular Formula C9H3F3N2S
Molecular Weight 228.19 g/mol
Melting Point 39.0 to 43.0℃ 
Boiling Point 331℃
Flash Point 154℃
Density 1.31 
Sensitive Moisture Sensitive, Heat Sensitive 
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Brand Ruifu Chemical

143782-23-4 - Specifications:

Items Specifications  Results
Appearance Off-White Powder  Off-White Powder  
Melting Point 39.0 to 43.0℃ 41.2℃
Loss on Drying <0.50% 0.19% 
Purity / Analysis Method >98.0% (HPLC)  98.8% 
Infrared Spectrum Consistent with Structure Complies 
1H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications
Application Intermediate of Enzalutamide (CAS: 915087-33-1)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

143782-23-4 - Hazard Statements:

H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.

143782-23-4 - Precautionary Statements:

P501: Dispose of contents/ container to an approved waste disposal plant.
P261: Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313: If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P301 + P312 + P330: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312: IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.

143782-23-4 - Application:

4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile (CAS: 143782-23-4) is used as an intermediate of Enzalutamide (CAS: 915087-33-1). Enzalutamide (XTANDI) is an oral androgen receptor antagonist, which is approved by the current clinical research and the US FDA (Food and Drug Administration), for the development of post-chemotherapy metastatic castration tolerance of prostate cancer Treatment (i.e. patients with prostate cancer after chemotherapy, cancer or cancer cells are still growing in such patients), can extend the survival of patients. In August 2012, the US FDA approved enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously been treated with Docetaxel.

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