Prucalopride Succinate Intermediate A CAS 143878-29-9 Purity >98.0% (HPLC)

Short Description:

Chemical Name: Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate 

CAS: 143878-29-9

Purity: >98.0% (HPLC)

Appearance: White to Off-White Solid

Intermediate of Prucalopride Succinate (CAS: 179474-85-2)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate (CAS: 143878-29-9) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Prucalopride Succinate Intermediates, Please contact: alvin@ruifuchem.com

Prucalopride Succinate Intermediates:

Chemical Properties:

Chemical Name Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate 
Synonyms Methyl 4-(Acetylamino)-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylate; Prucalopride Intermediate A; Prucalopride Succinate Intermediate A; Prucalopride Succinate Impurity N; Prucalopride Impurity 18
Stock Status In Stock, Commercial Production
CAS Number 143878-29-9
Molecular Formula C12H12ClNO4
Molecular Weight 269.68 g/mol
Boiling Point 492.0±45.0℃ at 760 mmHg
Density 1.400±0.06 g/cm3 
Refractive Index n20/D 1.6
COA & MSDS Available
Shipping Normal
Origin Shanghai, China
Category   Intermediate of Prucalopride Succinate (CAS: 179474-85-2)  
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White to Off-White Solid Off-White Solid   
Purity / Analysis Method >98.0% (HPLC)     99.19%
Loss on Drying <0.50% 0.15% 
Single Impurity  <1.00% Complies  
Total Impurities <2.00% Complies 
Infrared Spectrum Conforms to Structure Complies 
Proton NMR Spectrum Conforms to Structure Complies
Conclusion The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

143878-29-9 - Synthetic Route:

www.ruifuchemical.com

List of Solvents Used in Manufacturing
DMF, Toluene, Ethyl Acetate 

143878-29-9 - HPLC Method:

(1) Determination requirement: The relevant substances were determined by area normalization method
(2) Chromatographic conditions
Column: C18 reverse column, 4.6*250mm, 5μm
Column temperature: 40℃
Flow rate: 1.0ml/min
Detection wavelength: 254nm
Sample size: 10μL
Mobile phase:
Mobile phase B: acetonitrile
Mobile phase A: phosphate buffer (1.36g potassium dihydrogen phosphate was dissolved in 1L water; Adjust PH to 6.5 with potassium hydroxide, filter with 0.22 micron filter membrane, ultrasonic degassing)
Mobile phase ratio: 55-45
Dilute release agent: acetonitrile
Blank control: same diluent
(3) Sample configuration
Test solution: Take an appropriate amount of the product, weigh it accurately, dissolve it with a dissolving solvent and dilute it into a solution containing -mg per -ml. Filter it with a 0.22 micron filter membrane and use it as the test solution  

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory AuditFactory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
TransportationBy Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom SynthesisCan provide custom synthesis services to best fit your research needs.
Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate (CAS: 143878-29-9) is an intermediate of Prucalopride Succinate (CAS: 179474-85-2). Prucalopride Succinate is approved for the treatment of chronic constipation in Europe. Prucalopride Succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5- HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the central propulsive force for defecation. 

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