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4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8 Ibrutinib Intermediate Purity >98.5% (HPLC) Featured Image
  • 4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8 Ibrutinib Intermediate Purity >98.5% (HPLC)
  • 4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8 Ibrutinib Intermediate Purity >98.5% (HPLC)

4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8 Ibrutinib Intermediate Purity >98.5% (HPLC)

Short Description:

Name: 4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine

Synonyms: 3-Iodo-1H-Pyrazolo[3,4-d]pyrimidin-4-Amine

CAS: 151266-23-8

Purity: >98.5% (HPLC) 

Appearance: Light Yellow Powder

Intermediate of Ibrutinib (CAS: 936563-96-1) 

Contact: Dr. Alvin Huang  

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine (CAS: 151266-23-8) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Intermediates of Ibrutinib:

Ibrutinib CAS 936563-96-1                           
3-Hydroxypiperidine CAS 6859-99-0 
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid  CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine  CAS 151266-23-8 
Ibrutinib Deacryloylpiperidine CAS 330786-24-8 
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Chemical Properties:

Chemical Name 4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine 
Synonyms 3-Iodo-1H-Pyrazolo[3,4-d]pyrimidin-4-Amine; 4-Amino-3-Iodopyrazolo[3,4-d]pyrimidine; (3-Iodo-1H-Pyrazolo[3,4-d]pyrimidin-4-yl)amine; 3-iodo-4-Amino-1H-Pyrazolo[3,4-d]pyrimidine
CAS Number 151266-23-8
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C5H4IN5 
Molecular Weight 261.03  
Melting Point >300℃
Density 2.92±0.10 g/cm3
λmax 282nm(lit.)
Sensitive Light Sensitive 
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

Specifications:

Item Specifications Specifications
Appearance Light Yellow Powder  Light Yellow Powder 
Purity / Analysis Method >98.5% (HPLC)  98.87%
Loss on Drying <0.50% 0.41%
Total Impurities <1.50% 1.13%
Infrared Spectrum Conforms to Structure Conforms  
1H NMR Spectrum Conforms to Structure Conforms  
Test Standard Enterprise Standard Conforms  
Usage Intermediate of Ibrutinib (CAS: 936563-96-1)

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Russia, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

151266-23-8 - Risk and Safety:

Hazard Symbols Xn - Harmful
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S37 - Wear suitable gloves.
TSCA N
HS Code 2933599099

151266-23-8 - Application:

4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine (CAS: 151266-23-8) is an intermediate of Ibrutinib (CAS: 936563-96-1). Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to cure and easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit tumor cell proliferation and survival effectively.

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