Repaglinide Intermediate CAS 219921-94-5 Purity >99.0% (HPLC)

Short Description:

Chemical Name: (S)-3-Methyl-1-[2-(1-Piperidinyl)phenyl]butylamine N-Acetyl-L-Glutamate Salt

Synonyms: S-PPA; Repaglinide Related Compound A

CAS: 219921-94-5

Purity: >99.0% (HPLC)

Appearance: White to Almost White Powder 

Intermediate of Repaglinide (CAS: 135062-02-1)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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219921-94-5 - Description:

Ruifu Chemical is the leading manufacturer of (S)-3-Methyl-1-[2-(1-Piperidinyl)phenyl]butylamine N-Acetyl-L-Glutamate Salt (CAS: 219921-94-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Repaglinide Intermediates, contact: alvin@ruifuchem.com

219921-94-5 - Chemical Properties:

Chemical Name (S)-3-Methyl-1-[2-(1-Piperidinyl)phenyl]butylamine N-Acetyl-L-Glutamate Salt 
Synonyms S-PPA
Impurity   Repaglinide EP Impurity C / Repaglinide USP Related Compound A
Stock Status In Stock, Commercial Production  
CAS Number 219921-94-5
Molecular Formula C23H37N3O5
Molecular Weight 435.57 
Melting Point 168.0~171.0℃ 
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

219921-94-5 - Specifications:

Items Specifications  Results
Appearance White to Almost White Powder Almost White Powder
Solubility Soluble in Methanol. Sparingly Soluble in Water.
Insoluble in Dichloromethane
Complies 
Water by Karl Fischer  <1.00% 0.45%
Specific Optical +30.0° to +36.0° +34.1°
Purity / Analysis Method >99.0% (HPLC)  99.5%
Related Substances (HPLC)    
Total Impurities <1.00%  0.44%
Any Single Impurity <0.80%   0.31%
Isomer <1.00%  0.08%
1H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

219921-94-5 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes 41 - Risk of serious damage to eyes
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S24/25 - Avoid contact with skin and eyes.
HS Code 2942000000

219921-94-5 - Application:

(S)-3-Methyl-1-[2-(1-Piperidinyl)phenyl]butylamine N-Acetyl-L-Glutamate Salt (CAS: 219921-94-5) is an intermediate / impurity of Repaglinide (CAS: 135062-02-1).
Repaglinide, a type of medicines for treating diabetes, is insulinotropic agent which belongs to the non-sulfonylurea. It was developed by Boehringer Ingelheim from Germany, and won approval by FDA from the United States in December 1997. In 1998, it was successively listed in the United States and European countries, with commodity name as NovoNorm. Mainly used in the clinical treatment of type II diabetes (non-insulin-dependent) patients whose hyperglycemia can’t be effectively controlled via diet, weight loss and exercise. In 2008, FDA from the United States approved it going public for Novo Nordisk of Replaglinide + Metformin HCl, Prandimet, for treatment of type 2 diabetes.  

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