Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)

Short Description:

Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate

CAS: 27143-07-3

Purity: ≥99.0% (HPLC)

Appearance: Light Yellow to Yellow Powder

Intermediate of Apixaban (CAS: 503612-47-3)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Ruifu Chemical is the leading supplier of Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) with high quality, intermediate of Apixaban (CAS: 503612-47-3). Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Apixaban intermediates, E-mail: alvin@ruifuchem.com

Apixaban Intermediates:

Chemical Properties:

Chemical Name Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate
Synonyms Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate; (Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate; 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]; Apixaban-2; Apixaban Impurity 3
Stock Status In Stock, Commercial Production
CAS Number 27143-07-3 
Molecular Formula C11H13ClN2O3
Molecular Weight 256.69 g/mol
Melting Point 94℃ 
Density 1.23 
COA & MSDS Available
Origin Shanghai, China
Category   Intermediate of Apixaban (CAS: 503612-47-3) 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance Light Yellow to Yellow Powder  Complies      
Loss on Drying <0.50% 0.23% 
Purity / Analysis Method ≥99.0% (HPLC)  99.3% 
Infrared Spectrum Conforms to Structure Complies 
1 H NMR Spectrum  Consistent with Structure Complies
Conclusion The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

27143-07-3 - Synthetic Route:

www.ruifuchemical.com

List of Solvents Used in Manufacturing

No. Name CAS No. Molecular Formula
1 Ethyl Acetate CAS: 141-78-6 C4H8O2
2 Dichloromethane CAS: 75-09-2 CH2Cl2
3 Ethyl Alcohol CAS: 64-17-5 C2H5OH

27143-07-3 - Test Method:

5.3.1 Appearance: It should be light yellow to yellow powder. Visually, lay sufficient quantity of test product (without weighing) in a clean crystal dish on a white background (such as white paper) under natural light.
5.3.2 Identification: 1H-NMR has the same structure as the standard. 10~15mg of the sample was weighed into the nuclear magnetic tube, and 0.5mL of deuterium DMSO was added to fully dissolve the sample, and then tested with a nuclear magnetic resonance instrument of more than 400MHz.
5.3.3 Loss on drying : Weigh the sample about 1.0g and dry it for 3h in a drying oven at 85℃. The specific operation for weight loss calculation shall be performed according to the provisions of SOP-AP-QC-002-01 for Determination of Drying Weight Loss.
5.3.4.1 Chromatographic conditions:
Test reagents: 1) acetonitrile for chromatography 2) purified water 3) phosphoric acid
Column: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Mobile phase: A: Accurately measure 1.0ml phosphoric acid and 1000ml water, filter ultrasonic degassing.
B: Acetonitrile.
Gradient procedure: the following table
Time mobile phase A (%) Mobile phase B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Detector: 210nm
Column temperature: 35℃
Flow speed: 1.0ml/min
Sample size: 5µl
5.3.4.2 Solution preparation:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Blank solution: diluent shall be used as blank solution.
5.3.4.5 Test product solution: Weigh the test product about 12.5mg in a 25ml volumetric bottle and dissolve it with diluent to the scale.
5.3.4.6 Operation procedure: After the baseline of the instrument is stable, one to two injections of blank solution are advanced, and then the solution of the test product is analyzed. The chromatogram is saved and analyzed, blank peak is deducted, and the main peak purity and single impurity results on the chromatogram of the test product are recorded by area normalization method. After the analysis, the chromatogram was printed.  

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) is used as an intermediate in the synthesis of Apixaban (CAS: 503612-47-3). Apixaban is a new type of oral factor Xa inhibitor jointly developed by Bristol-Myers Squibb and Pfizer. The trade name is Erroto. It is a new type of oral anticoagulant. By inhibiting an important coagulation factor Xa, apixaban can prevent thrombin production and thrombosis. Apixaban was developed by Bristal-Myers squibb Company. It has good bioavailability and high selectivity. It was listed in China in 2013. Apixaban is safe, the possibility of drug interaction is small, and there are many ways to eliminate it, which is expected to be used in special groups suffering from liver disease or kidney function damage.

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