Dimethyl Suberimidate Dihydrochloride (DMS) CAS 34490-86-3 Purity >98.0% (AT)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Dimethyl Suberimidate Dihydrochloride (CAS: 34490-86-3) with high quality. Ruifu Chemical can provide competitive price, excellent service, small and bulk quantities available. Purchase Dimethyl Suberimidate Dihydrochloride, Please contact: alvin@ruifuchem.com
| Chemical Name | Dimethyl Suberimidate Dihydrochloride |
| Synonyms | DMS; Dimethyl Suberimidate 2HCl; Suberimidic Acid Dimethyl Ester Dihydrochloride; Dimethyl Ester Octanediimidic Acid Dihydrochloride |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 34490-86-3 |
| Molecular Formula | C10H20N2O2·2HCl |
| Molecular Weight | 273.20 g/mol |
| Melting Point | 213.0~214.0℃(lit.) |
| Density | 1.01g/cm3 |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Hygroscopic, Heat Sensitive, Moisture Sensitive |
| Water Solubility | Soluble in Water |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White Powder | White Powder |
| Purity / Analysis Method | 97.5~102.5% (Argentmetric Titration) | 99.0% |
| Water by Karl Fischer | <1.00% | 0.3% |
| Loss on Drying | <1.00% | 0.5% |
| Residue on Ignition | <0.20% | <0.10% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
FLUKA BRAND F CODES 3-10-21
TSCA Yes
Hazard Class IRRITANT
HS Code 2925290090
Dimethyl Suberimidate Dihydrochloride (CAS: 34490-86-3), Bioconjugation Reagents, Cross-linkers.
DMA (Dimethyl Adipimidate.2HCl), DMP (Dimethyl Pimelimidate.2HCl) and DMS (Dimethyl Suberimidate.2HCl) are water soluble, membrane permeable, homobifunctional imidoester crosslinkers. The imidoester functional group is one of the most specific acylating groups available for the modification of primary amines and has minimal cross reactivity toward other nucleophilic groups in proteins. In addition, the imidoamide reaction product does not alter the overall charge of the protein, potentially retaining the native conformation and activity of the protein.
Soluble in water. Used to crosslink membrane proteins. Reactive towards amino groups. Amidine bond retains net charge character of protein. Reaction pH: 8~10.
Dimethyl Suberimidate Dihydrochloride is used as a homobifunctional cross-linking reagent for amino groups. It is also used for the modification of tyrosinase to produce biocatalytic enzymatic flow-through detectors. It serves as a cross-linker for preparation of collagen-calcium phosphate composites. Further, it is used in the treatment of avian myeloblastosis virus.
The following protocol is adapted from a procedure described by Packman and Perham.
A. Materials Required
1. Crosslinking Buffer: 0.2 M triethanolamine, pH 8.0. Do not use buffers that contain primary amines, as these buffers will compete with the crosslinking reaction.
2. Stop Solution: Glacial acetic acid. Alternatively, Tris or glycine can be used to quench the reaction.
B. Procedure
1. Prepare the appropriate protein sample in crosslinking buffer.
2. Add a 10-fold molar excess of the cross-linker to the protein when the protein concentration is above 5 mg/ml. If the protein concentration is below 5 mg/ml add a 20- to 30-fold molar excess of the crosslinker.
3. Incubate the reaction at room temperature for 30-60 minutes.
4. Add glacial acetic acid at a 1:4 ratio to the sample to stop the reaction. Alternatively, stop the reaction by adding Tris or glycine at a 20-50 mM final concentration.
1. Imidoester crosslinkers are moisture sensitive. To avoid condensation onto the product, fully equilibrate vial to room temperature before opening (typically requires at least 30 minutes).
2. For imidoester crosslinking reactions use buffers such as phosphate, borate, carbonate and HEPES that do not contain primary amines. Imidoesters react with amines at pH 7-10. For optimal crosslinking efficiency, use pH 8-9.
3. Imidoester crosslinkers cannot be stored in solution because the imidate moiety is easily hydrolyzed. DMA (Dimethyl Adipimidate.2HCl), DMP (Dimethyl Pimelimidate.2HCl) and DMS (Dimethyl Suberimidate.2 HCl) are non-cleavable forms of imidoester crosslinkers. By contrast, crosslinks with DTBP can be cleaved by
reducing the disulfide bond of the spacer arm with 100-150 mM DTT at 37℃ for 30 minutes.
