N-(4-Cyanophenyl)glycine CAS 42288-26-6 Dabigatran Etexilate Mesylate Intermediate Purity >99.0% (HPLC)

Short Description:

Chemical Name: N-(4-Cyanophenyl)glycine 

CAS: 42288-26-6

Purity: >99.0% (HPLC)

Appearance: White or Off-White Powder 

Intermediate of Dabigatran Etexilate Mesylate

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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42288-26-6 - Description:

Shanghai Ruifu Chemical is the leading manufacturer of N-(4-Cyanophenyl)glycine (CAS: 42288-26-6) with high quality, intermediate of Dabigatran Etexilate Mesylate (CAS: 872728-81-9). Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase N-(4-Cyanophenyl)glycine, Please contact: alvin@ruifuchem.com

42288-26-6 - Chemical Properties:

Chemical Name N-(4-Cyanophenyl)glycine   
Synonyms Dabigatran Etexilate Intermediate 2; N-(p-Cyanophenyl)glycine; N-(4-Cyano-Phenyl)-Glycine; 2-[(4-Cyanophenyl)amino]acetic Acid; 2-(4-Cyanophenylamino)acetic Acid; Dabigatran Cyanopheny Impurity
Stock Status In Stock, Commercial Production  
CAS Number 42288-26-6
Molecular Formula C9H8N2O2
Molecular Weight 176.18 g/mol
Melting Point 227.0~230.0℃ 
Density 1.30±0.10 g/cm3 
COA & MSDS Available
Free Sample  Available
Origin Shanghai, China
Category   Intermediate of Dabigatran Etexilate Mesylate (CAS: 872728-81-9) 
Brand Ruifu Chemical

42288-26-6 - Specifications:

Items Specifications  Results
Appearance White to Off-White Powder  Off-White Powder 
Melting Point 227.0~230.0℃ 227.0~228.0℃
Loss on Drying <0.50% 0.09% 
Residue on Ignition <0.50% 0.26% 
Assay / Analysis Method 98.0%~102.0% 100.6%
Purity / Analysis Method >99.0% (HPLC)  99.5% 
4-Aminobenzonitrile <1.00% Complies
Other Single Impurity <0.25% <0.25%
Total Impurities <1.00% 0.50%
Heavy Metals <10ppm <10ppm
1H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications
Application Intermediate of Dabigatran Etexilate Mesylate (CAS: 872728-81-9)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

42288-26-6 - Flow Chart:

www.ruifuchemical.com

42288-26-6 - MOA: HPLC

Mobile Phase Buffer Solution (0.025mol/L KH2PO4, pH=3.1):Acetonitrile=60:40
Column Kromasil 100-5 C18 250*4.6mm*5μm
Dilute Water:Acetonitrile=50:50
Flow 1.0mL/min
Column Temperature 25℃
Run Time 30min
Wavelength 254nm
Injection Volume 10μL

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

42288-26-6 - Application:

N-(4-Cyanophenyl)glycine (CAS: 42288-26-6), intermediate of Dabigatran Etexilate Mesylate (CAS: 872728-81-9). Dabigatran Etexilate is a new synthetic direct thrombin inhibitor. It is a precursor of dabigatran and a non peptide thrombin inhibitor. After oral administration, Dabigatran etexilate was transformed into dabigatran with direct anticoagulant activity in vivo. Dabigatran binds to the fibrin specific binding site of thrombin and prevents fibrinogen from cleaving to fibrin, thus blocking the final step of coagulation cascade network and thrombosis. Dabigatran can dissociate from fibrin thrombin conjugates and play a reversible anticoagulant effect.

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