Apixaban Intermediate CAS 545445-44-1 Purity >98.0% (HPLC)

Short Description:

Chemical Name: 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one 

CAS: 545445-44-1

Purity: >98.0% (HPLC)

Appearance: Light Yellow Powder  

Intermediate of Apixaban (CAS: 503612-47-3)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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545445-44-1 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445-44-1) with high quality, intermediate of Apixaban (CAS: 503612-47-3). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Apixaban Intermediates, Please contact: alvin@ruifuchem.com

545445-44-1 - Chemical Properties:

Chemical Name 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one
Synonyms Apixaban Intermediate 1; 5,6-Dihydro-3-(4-Morpholinyl)-1-[4-(2-Oxo-1-Piperidinyl)phenyl]-2(1H)-Pyridinone; 5-Morpholin-4-yl-1-[4-(2-Oxopiperidin-1-yl)phenyl]-2,3-Dihydropyridin-6-one; Apixaban Impurity A
Stock Status In Stock, Commercial Production  
CAS Number 545445-44-1
Molecular Formula C20H25N3O3
Molecular Weight 355.43 g/mol
Melting Point >199℃(dec.)  
Density 1.267 g/mL
COA & MSDS Available
Origin Shanghai, China
Category   Intermediate of Apixaban (CAS: 503612-47-3)  
Brand Ruifu Chemical

545445-44-1 - Specifications:

Items Specifications  Results
Appearance Light Yellow Powder  Light Yellow Powder 
Loss on Drying <0.50% 0.16% 
Residue on Ignition <0.20% 0.07% 
Purity / Analysis Method >98.0% (HPLC Area)  99.12% 
Any Individual Impurity <0.50% <0.50%
Total Impurities <2.00% 0.88%
1H NMR Spectrum Consistent with Structure Conforms
LC-MS for Identification Conforms Conforms
Conclusion The product has been tested and complies with the given specifications
Application Intermediate of Apixaban (CAS: 503612-47-3)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

545445-44-1 - Application:

3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445-44-1) is an intermediate of Apixaban (CAS: 503612-47-3).
Apixaban is a new type of oral Xa factor inhibitor jointly developed by Bristol-Myers Squibb and Pfizer. The trade name is Eratol, which is a new type of oral anticoagulant. By inhibiting an important coagulation factor Xa, Apixaban can prevent thrombin production and thrombosis. On April 26, 2007, Bristol-Myers Squibb joined hands with Pfizer to announce the cooperation in the development of a new oral anticoagulant Apixaban owned by Bristol-Myers Squibb as an upgraded alternative to Warfarin. In May 2011, Apixaban was the first to approve the prevention of venous thrombosis in adult patients undergoing elective hip or knee replacement surgery in 27 EU countries, Iceland and Norway. On November 20, 2012, the European Commission approved Ererto (Apixaban) for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF) with one or more risk factors. Subsequently, the Canadian Food and Drug Administration, Japan, and the US FDA approved Ererto (Apixaban) for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF) with one or more risk factors. On April 12, 2013, the new anticoagulant drug Eloto (ELIQUIS)(Apixaban) jointly developed by Bristol-Myers Squibb and Pfizer was officially announced to be listed in China.  

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