(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-Leucine Salt CAS 608141-43-1 Purity ≥99.0% (HPLC) e.e ≥99.0% Apremilast Intermediate

Short Description:

Chemical Name: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-Leucine Salt

CAS: 608141-43-1

Purity: ≥99.0% (HPLC)

Enantiomeric Excess (e.e): ≥99.0%

Appearance: White to Off-White Solid

Intermediate of Apremilast (CAS: 608141-41-9)

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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608141-43-1 - Description:

Ruifu Chemical is the leading manufacturer of (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-Leucine Salt (CAS: 608141-43-1) with high quality, intermediate of Apremilast (CAS: 608141-41-9).
Apremilast is used for the treatment of active psoriatic arthritis (PsA) and moderate to severe chronic plaque psoriasis (PSOR). Ruifu Chemical can provide high-quality Apremilast intermediates and impurities.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Apremilast intermediates and impurities or other products, please e-mail: alvin@ruifuchem.com

Intermediates of Apremilast:

Apremilast	CAS 608141-41-9
3-Acetamidophthalic Anhydride	CAS 6296-53-3
3-Ethoxy-4-Methoxybenzonitrile	CAS 60758-86-3
3-Ethoxy-4-Methoxybenzaldehyde	CAS 1131-52-8
1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanamine	CAS 253168-94-4
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanamine	CAS 608141-42-0
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-LeucineSalt	CAS 608141-43-1

608141-43-1 - Chemical Properties:

Chemical Name	(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-Leucine Salt
Synonyms	(S)-2-(3-Ethoxy-4-Methoxyphenyl)-1-(Methylsulphonyl)-Eth-2-ylamine N-Acetyl-L-Leucine Salt; (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanamine (S)-2-Acetamido-4-Methylpentanoate; N-Acetyl-L-leucine Compound with (alphaS)-3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)methyl]benzenemethanamine; Apremilast Impurity 1
Stock Status	In Stock
CAS Number	608141-43-1
Molecular Formula	C12H19NO4S.C8H15NO3
Molecular Weight	446.56 g/mol
Storage Temperature	Store at 2-8℃ Refrigerator, Sealed Storage, Away From Moisture
Shipping Conditions	Ambient
Certificate of Analysis	Available
Origin of Product	Shanghai, China
Product Categories	Apremilast Intermediate
Brand	Ruifu Chemical

608141-43-1 - Specifications:

Items	Specifications	Results
Appearance	White to Off-White Solid	Conforms
Purity / Analysis Method	≥99.0% (HPLC)	99.99%
Enantiomeric Excess (e.e)	≥99.0%	100.00%
Infrared Spectrum	Conforms to Structure	Conforms
1H NMR Spectrum	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Apremilast (CAS: 608141-41-9)

608141-43-1 - Package/Storage/Shipping:

Package: Fluorinated bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

608141-43-1 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

608141-43-1 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

608141-43-1 - Application:

(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylamine N-Acetyl-L-Leucine Salt (CAS: 608141-43-1), intermediate of Apremilast (CAS: 608141-41-9). Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.