Chinese Professional 5-Fluorocytosine - 4-Guanidinobenzoic Acid Hydrochloride CAS 42823-46-1 Nafamostat Mesylate and Camostat Mesilate Intermediate – Ruifu
Chinese Professional 5-Fluorocytosine - 4-Guanidinobenzoic Acid Hydrochloride CAS 42823-46-1 Nafamostat Mesylate and Camostat Mesilate Intermediate – Ruifu Detail:
Commercial Supply; High Purity and Competitive Price
Nafamostat Mesylate (CAS: 82956-11-4) Related Intermediates:
4-Guanidinobenzoic Acid Hydrochloride CAS: 42823-46-1
6-Bromo-2-naphthol CAS: 15231-91-1
6-Amidino-2-naphthol Methanesulfonate CAS: 82957-06-0
N,N′-Dicyclohexylcarbodiimide (DCC) ; CAS: 538-75-0
4-Dimethylaminopyridine (DMAP) CAS: 1122-58-3
Camostat Mesilate (CAS: 59721-29-8) Related Intermediates
4-Guanidinobenzoic Acid Hydrochloride CAS: 42823-46-1
N,N′-Dicyclohexylcarbodiimide (DCC) CAS: 538-75-0
4-Dimethylaminopyridine (DMAP) CAS: 1122-58-3
Chemical Name | 4-Guanidinobenzoic Acid Hydrochloride |
Synonyms | 4-Guanidinobenzoic Acid HCl; N-(4-Carboxyphenyl)Guanidine Hydrochloride |
CAS Number | 42823-46-1 |
CAT Number | RF-PI119 |
Stock Status | In Stock, Production Scale Up to Tons |
Molecular Formula | C8H10ClN3O2 |
Molecular Weight | 215.64 |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | White or Off-White Crystalline Powder |
Purity | ≥99.0% |
Melting Point | 280.0~285.0℃ |
Moisture (K.F) | ≤0.50% |
Heavy Metals (Pb) | ≤5ppm |
Test Standard | Enterprise Standard |
Usage | Nafamostat Mesylate and Camostat Mesilate Intermediates |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Nafamostat Mesylate (CAS: 82956-11-4), an anti-pancreatitis drug was prepared from 4-Guanidinobenzoic Acid Hydrochloride (CAS: 42823-46-1) and 6-Amidino-2-naphthol Methanesulfonate (CAS: 82957-06-0) in the presence of DCC (CAS: 538-75-0) with DMAP (CAS: 1122-58-3)as catalyst with an overall yield of about 28%. 6-Amidino-2-naphthol Methanesulfonate (CAS: 82957-06-0) was prepared from 6-Bromo-2-naphthol (CAS: 15231-91-1) by cyanidation,addition,aminolysis and salt formation.
Camostat Mesilate (CAS: 59721-29-8), a drug for pancreatitis treatment was prepared from p-guanidinobenzoic acid hydrochloride and N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate in the presence of DCC(N,N-Dicyclohexylcarbodiimide, CAS: 538-75-0) using DMAP (4-Dimethylaminopyridine, CAS: 1122-58-3) as catalyst. p-Guanidinobenzoic Acid Hydrochloride (CAS: 42823-46-1) was prepared from p-aminobenzoic acid and cyanamide by optimization of reaction conditions.This process is simple with easily available starting materials,which is suitable for industrial production.
Camostat Mesilate (CAS: 59721-29-8) is a broad spectrum protease inhibitor useful in the treatment of chronic pancreatitis. Camostat mesylate is a broad spectrum protease inhibitor useful in the treatment of chronic pancreatitis. It is a proteolytic enzyme inhibitor that inhibits digestive enzymes in pancreatic fluid (e.g., trypsin) and suppresses abnormal increases of the enzyme activity, leading to ameliorating inflammatory symptoms and pain associated with pancreatitis.
Nafamostat Mesylate (CAS: 82956-11-4) is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Product detail pictures:
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