Chinese wholesale 3-Benzyl-6-bromo-2-chloroquinoline - (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS 85977-52-2 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu

Manufacturer with High Quality and Competitive Price
Commercial Supply Palonosetron Hydrochloride and Related Intermediates:
1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 1914-65-4
(S)-1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

(S)-1,2,3,4-tetrahydro-naphthoic acid CAS: 85977-52-2 Route of Synthesis 

Package: Bottle, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-1,2,3,4-Tetrahydro-Naphthoic Acid (CAS: 85977-52-2) with high quality, used in synthesis of active pharmaceutical ingredient (API). It is an intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).

Palonosetron Hydrochloride (CAS: 135729-62-3) is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention. With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.