Chloral Hydrate CAS 302-17-0 Assay ≥99.5% (Titration) High Purity

Short Description:

Chemical Name: Chloral Hydrate 

CAS: 302-17-0

Assay: ≥99.5% (Titration)

White to Off-White Needle Crystalline Solid 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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302-17-0 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Chloral Hydrate (CAS: 302-17-0) with high quality. Ruifu Chemical has been supplying Chloral Hydrate more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Chloral Hydrate, please contact us by e-mail: alvin@ruifuchem.com

302-17-0 - Chemical Properties:

Chemical Name Chloral Hydrate
Synonyms Trichloroacetaldehyde Hydrate; 2,2,2-Trichloroethane-1,1-Diol;
Stock Status In Stock, Commercial Production  
CAS Number 302-17-0
Molecular Formula C2H3Cl3O2
Molecular Weight 165.39 g/mol
Melting Point 57℃(lit.) 
Boiling Point 97℃
Density 1.43g/ml at 20℃ 
Sensitive Light Sensitive 
Solubility  Very Soluble in Water, Freely Soluble in Ethanol (96 percent) 
Storage Temperature Store Long-Term at 2-8℃
COA & MSDS Available
Origin of Product    Shanghai, China
Product Categories
Pharmaceutical Intermediates
Brand Ruifu Chemical

302-17-0 - Specifications:

Items Specifications  Results
Appearance White to Off-White Needle Crystalline Solid  Conforms  
Assay / Analysis Method ≥99.5% (Titration)  99.61%
Appearance of the Solution Clear and Colourless  Complies  
Melting Point 51.0-54.0℃ 52.0-54.0℃
pH (10 %, 20℃) 3.5-5.5 4.6
Chloride (Cl) ≤100ppm <100ppm
Loss on Drying ≤0.50% 0.4%
Residue on Ignition ≤0.10% <0.01%
Heavy Metals (Pb) ≤20ppm <10ppm 
Arsenic (AS2O3) <1ppm <1ppm
Chloral-Alcoholate Complies to EP10 Standard Complies
Non-Volatile Residue ≤0.10% Complies
Infrared Spectrum Conforms to Structure   Conforms 
Conclusion The product has been tested and complies with the given specifications

302-17-0 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: May be air or light sensitive. Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire, moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

302-17-0 - European Pharmacopoeia 11.0:

Chlorali Hydras
C2H3Cl3O2 Mr 165.4
[302-17-0]
DEFINITION
2,2,2-Trichloroethane-1,1-diol.
Content: 98.5 per cent to 101.0 per cent.
CHARACTERS
Appearance: colourless, transparent crystals.
Solubility: very soluble in water, freely soluble in ethanol (96 per cent).
IDENTIFICATION
A. To 10 mL of solution S (see Tests) add 2 mL of dilute sodium hydroxide solution R. The mixture becomes cloudy and, when heated, gives off an odour of chloroform.
B. To 1 mL of solution S add 2 mL of sodium sulfide solution R. A yellow colour develops which quickly becomes reddish-brown. On standing for a short time, a red precipitate may be formed.
TESTS
Solution S. Dissolve 3.0 g in carbon dioxide-free water R and dilute to 30 mL with the same solvent.
Appearance of solution. Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
pH (2.2.3): 3.5 to 5.5 for solution S.
Chloral alcoholate. Warm 1.0 g with 10 mL of dilute sodium hydroxide solution R, filter the supernatant solution and add 0.05 M iodine dropwise until a yellow colour is obtained. Allow to stand for 1 h. No precipitate is formed.
Chlorides (2.4.4): maximum 100 ppm.
Dilute 5 mL of solution S to 15 mL with water R.
Heavy metals (2.4.8): maximum 20 ppm.
10 mL of solution S diluted to 20 mL with water R complies with test A. Prepare the reference solution using lead standard solution (1 ppm Pb) R.
Non-volatile residue: maximum 0.1 per cent.
Evaporate 2.000 g on a water-bath. The residue weighs a maximum of 2 mg.
ASSAY
Dissolve 4.000 g in 10 mL of water R and add 40.0 mL of 1 M sodium hydroxide. Allow to stand for exactly 2 min and titrate with 0.5 M sulfuric acid, using 0.1 mL of phenolphthalein solution R as indicator. Titrate the neutralised solution with 0.1 M silver nitrate, using 0.2 mL of potassium chromate solution R as indicator. Calculate the number of millilitres of 1 M sodium hydroxide used by deducting from the volume of 1 M sodium hydroxide, added at the beginning of the titration, the volume of 0.5 M sulfuric acid used in the 1st titration and two-fifteenths of the volume of 0.1 M silver nitrate used in the 2nd titration. 1 mL of 1 M sodium hydroxide is equivalent to 0.1654 g of C2H3Cl3O2.
STORAGE
In an airtight container.

302-17-0 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

302-17-0 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

302-17-0 - Risk and Safety:

Risk Codes
R25 - Toxic if swallowed
R36/38 - Irritating to eyes and skin.
R39/23/24/25 -
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R11 - Highly Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
R36 - Irritating to the eyes
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25 - Avoid contact with eyes.
S23 - Do not breathe vapour.
S36/37 - Wear suitable protective clothing and gloves.
S16 - Keep away from sources of ignition.
S27 - Take off immediately all contaminated clothing.
UN IDs UN 3286 3/PG 2
WGK Germany 2
RTECS FM8750000
HS Code 2911000000
Hazard Class 6.1(b)
Packing Group III

302-17-0 - Application:

Chloral Hydrate (CAS: 302-17-0), was first used as a sedative and hypnotic in Germany in the 1870s. Chloral Hydrate is used in the short-term treatment of insomnia (to help you fall asleep and stay asleep for a proper rest) and to relieve anxiety and induce sleep before surgery. It is also used after surgery for pain and to treat alcohol.
Chloral Hydrate is a hypnotic and anticonvulsant. Hypnotic dose can induce sleep within 30 minutes, the hypnotic effect is mild, does not shorten REMS sleep, no obvious aftereffects. The hypnotic mechanism may be similar to that of barbiturates, causing approximate physiological sleep without obvious after-effect. Larger doses have anticonvulsant effects and can be used for convulsions caused by high fever, tetanus and epilepsy in children. Large doses can cause coma and anesthesia. Inhibit the respiratory and vasomotor centers of the medulla oblongata, leading to death.

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