Cl-HOBt CAS 26198-19-6 6-Chloro-1-Hydroxybenzotriazole Dihydrate Purity >99.0% (HPLC) Factory

Short Description:

6-Chloro-1-Hydroxybenzotriazole Dihydrate 

Synonyms: Cl-HOBT; 6-Cl-HOBt 

CAS: 26198-19-6

Purity: >99.0% (HPLC)

Appearance: White Powder 

Coupling Reagents, High Quality 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 6-Chloro-1-Hydroxybenzotriazole Dihydrate (Cl-HOBT) (CAS: 26198-19-6) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Cl-HOBT, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name 6-Chloro-1-Hydroxybenzotriazole Dihydrate 
Synonyms Cl-HOBt; 6-Cl-HOBt; HOBt(6-Cl); 6-Chloro-1H-Benzotriazol-1-ol; 6-ChloroBenzotriazole-1-ol; 6-Chloro-1-Hydroxy-1H-Benzotriazole; 1-Hydroxy-6-Chlorobenzotriazole; 1-Hydroxy-6-Chloro-Benzotriazole; 6-Chloro-1H-benzo[d][1,2,3]triazol-1-ol
Stock Status In Stock, Mass Production
CAS Number 26198-19-6
Molecular Formula C6H4ClN3O·2H2O
Molecular Weight 205.60 g/mol
Melting Point 193.0~200.0℃ 
Density 1.71±0.10 g/cm3 
Storage Temp.  Cool & Dry Place (2~8℃) 
COA & MSDS Available
Category   Coupling Reagents 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White Powder  White Powder
Melting Point 193.0~200.0℃ 194.9~195.8℃
Water by Karl Fischer  <10.0% Complies  
Purity / Analysis Method >99.0% (HPLC)  99.9% 
Infrared Spectrum Conforms to Structure Complies      
1 H NMR Spectrum  Conforms to Structure Complies      
Conclusion The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 
Caution: For safe storage and transport the material was desensitized with two equivalents of water. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

26198-19-6 - Risk and Safety:

Risk Codes
R22 - Harmful if swallowed
R44 - Risk of explosion if heated under confinement
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R2 - Risk of explosion by shock, friction, fire or other sources of ignition
Safety Description
S15 - Keep away from heat.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S35 - This material and its container must be disposed of in a safe way.
UN IDs UN 1325 4.1/PG 2

Application:

6-Chloro-1-Hydroxybenzotriazole Dihydrate (Cl-HOBt; 6-Cl-HOBt) (CAS: 26198-19-6) is a reagent to suppress racemization in peptide coupling, which is not toxic. Reagent in peptide synthesis, has also been introduced into solid-phase synthesis.
6-Cl-HOBt is an alternative to HOBt. The chlorine atom attached to the ring increases the acidity and the effectiveness as a leaving group of 6-Cl-HOBt compared to HOBt. Like HOBt, 6-Cl-HOBt efficiently suppresses racemization during coupling. Cl-HOBt can be used in place of HOBt with equal or superior results. 6-Cl-HOBt increases the efficiency of carbodiimode mediated reactions by generating an active ester that prone for Amidation.
6-Cl-HOBt is a good compromise between HOAt and HOBt in terms of reactivity and price.

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