D-Prolinol CAS 68832-13-3 Purity >99.0% (GC) E.E >99.0% Factory High Quality

Short Description:

Chemical Name: D-Prolinol

Synonyms: (R)-(-)-Prolinol; H-D-Pro-ol

CAS: 68832-13-3

Purity: >99.0% (GC) E.E: >99.0%

Appearance: Colorless Transparent Liquid

Amino Acid Derivative, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of D-Prolinol (CAS: 68832-13-3) with high quality. Ruifu Chemical supply a series of amino acids derivatives and peptide synthesis reagents. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in D-Prolinol, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	D-Prolinol
Synonyms	D(-)Prolinol; (R)-Prolinol; (R)-(-)-Prolinol; (R)-(-)-2-(Hydroxymethyl)pyrrolidine; (R)-(-)-2-Pyrrolidinemethanol; (R)-Pyrrolidin-2-Methanol; (R)-1-Pyrrolidin-2-ylmethanol; H-D-Pro-ol
Stock Status	In Stock, Production Capacity 50 Tons per Month
CAS Number	68832-13-3
Molecular Formula	C5H11NO
Molecular Weight	101.15
Boiling Point	74.0~76.0℃/2 mm Hg(lit.)
Flash Point	86℃(186°F)
Sensitive	Hygroscopic. Air Sensitive, Moisture Sensitive, Heat Sensitive
Water Solubility	Completely Soluble in Water
Solubility	Very Soluble in Alcohol
Storage Temp.	Sealed in Dry, Room Temperature
COA & MSDS	Available
Brand	Ruifu Chemical

Safety Information:

Hazard Codes	Xi	F	3-10-23
Risk Statements	36/37/38	Hazard Note	Irritant/Air Sensitive
Safety Statements	26-36-24/25-26/36	Hazard Class	IRRITANT
RIDADR	NA 1993 / PGIII	HS Code	2922199090
WGK Germany	3

Specifications:

Item	Inspection Standard	Results
Appearance	Colorless Transparent Liquid	Conforms
D-Prolinol Purity	>99.0% (GC)	99.61%
Boiling Point	74.0~76℃	Conforms
Specific Rotation [α]20/D	-33.0° to -29.0°（C=1, C7H8）	-31.0°
E.E	>99.0%	99.90%
Water (K.F)	<0.50%	0.33%
Refractive Index n20/D	1.483~1.490	Conforms
Density (20°C)	1.035~1.040	Conforms
Infrared Spectrum	Conforms to Structure	Conforms
Conclusion	This Product by Inspection Accords with the Enterprise Standard
Main Usage	Chiral Amino Alcohols; Chiral Resolving Agents

Package & Storage:

Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

D-Prolinol (CAS: 68832-13-3), the D-enantiomer of prolinol, is a chiral amino alcohol used as a chiral resolver in organic synthesis. In recent years, with the rapid development of asymmetric catalysis technology, D-Prolinol has become an excellent ligand for metal coordination catalysis, widely used in asymmetric metal alkylation reaction, Michael addition reaction, phase transfer catalysis and other important organic synthesis. D-Prolinol makes use of an intermediate of pharmaceuticals.

Synthesis methods: There are two main methods for the synthesis of D-Prolinol: (1) Indirect reduction method: taking D-Proline as raw material, esterification, neutralization, and then reduction with NaBH4; (2) Direct reduction method: D-Proline was directly reduced by AlLiH4. The former process is complicated and the yield is low (42.6%). The latter operation is harsh, low temperature ice bath drops, high cost, deep product color. The author directly reduced D-proline to D-prolinol by using the reduction system of NaBH4 additive I2 (see the figure below), which has low cost, good quality, stable process, simple operation and easy industrialization.