Deoxycholic Acid CAS 83-44-3 Purity >98.0% (T) (HPLC)

Short Description:

Chemical Name: Deoxycholic Acid

Synonyms: Choleic Acid; DCA 

CAS: 83-44-3

Purity: >98.0% (T) (HPLC)

Appearance: White Crystal Powder 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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83-44-3 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Deoxycholic Acid (CAS: 83-44-3) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Deoxycholic Acid, Please contact: alvin@ruifuchem.com

83-44-3 - Chemical Properties:

Chemical Name Deoxycholic Acid 
Synonyms Choleic Acid; DCA; 3α,12α-Dihydroxy-5β-Cholanic Acid; 7-Deoxycholic acid; Desoxycholic Acid; Cholanoic Acid; Ursodeoxycholic Acid Impurity
Stock Status In Stock, Commercial Production  
CAS Number 83-44-3
Molecular Formula C24H40O4
Molecular Weight 392.58 g/mol
Melting Point 172.0~178.0℃ 
Water Solubility  Slightly Soluble in Water 
Solubility in Methanol  Almost Transparency 
Stability Stable. Combustible. Incompatible with Strong Oxidizing Agents.
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Brand Ruifu Chemical

83-44-3 - Specifications:

Items Specifications  Results
Appearance White Crystal Powder  White Crystal Powder 
Melting Point 172.0~178.0℃ 175.2℃
Specific Rotation [a]20/D +53.0° to +57.0° (C=1 in EtOH) +54.5°
Loss on Drying <0.50% 0.07% 
Residue on Ignition <0.20% 0.1% 
Cholic Acid (TLC) <0.50% 0.3%
Heavy Metals (as Pb) ≤20ppm <10ppm 
Purity / Analysis Method >98.0% (HPLC)  98.56% 
Infrared Spectrum Consistent with Structure Complies 
Conclusion The product has been tested and complies with the given specifications
Shelf Life 2 Years When Properly Stored

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Store away from oxidizing agents. 
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

83-44-3 - Risk and Safety:

Hazard Symbols Xn - Harmful
Risk Codes R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
R37 - Irritating to the respiratory system
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S22 - Do not breathe dust.
UN IDs UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS FZ2100000
TSCA Yes
HS Code 2918190090
Toxicity LD50 oral in rat: 1gm/kg

83-44-3 - Application:

Deoxycholic Acid (CAS: 83-44-3) is usually conjugated with glycine or taurine and acts as a detergent in the emulsification of fats for intestinal absorption.
Deoxycholic Acid was developed by Kythera biopharpharmaceuticals, Inc., in April 2015 by the U. S. Food and Drug Administration (FDA). Approved as the first local lipid-dissolving drug in the world. Deoxycholic acid is a kind of free bile acid existing in bile, which has strong surface activity, can destroy and dissolve cell membrane, and reduce the dissolution of small local subcutaneous fat. In clinical trials, deoxycholic acid was effective in eliminating submental fat and improving overall appearance compared to placebo.
Deoxycholic Acid is a secondary bile acid involved in the emulsification and solubilization of dietary fat. A 10 mg/mL injectable solution of chemically synthesized Deoxycholic Acid is indicated in various countries, including the USA (KybellaTM)[9] and several within Europe/the EU (BelkyraTM) to improve the appearance of moderate to severe submental convexity or fullness associated with SMF in adults, where it is currently the only approved minimally invasive treatment for submental contouring.
Sodium Deoxycholate, the sodium salt of Deoxycholic Acid, is often used as a biological detergent to lyse cells and solubilise cellular and membrane components.  

83-44-3 - Mechanism of Action:

As a bile acid, Deoxycholic Acid emulsifies fat in the gut. Synthetically derived deoxycholic acid, when injected, stimulates a targeted breakdown of adipose cells by disrupting the cell membrane and causing adipocytolysis. This results in an inflammatory reaction and clearing of the adipose tissue remnants by macrophages. Deoxycholic Acid's actions are reduced by albumin and tissue-associated proteins, therefore its effect is limited to protein-poor subcutaneous fat tissue. Protein-rich tissues like muscle and skin are unaffected by deoxycholic acid, contributing to its safety.

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