Despropionyl Ramelteon Hydrochloride CAS 196597-80-5 Purity >98.0% (HPLC)

Short Description:

Chemical Name: (S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride

Synonyms: Despropionyl Ramelteon Hydrochloride

CAS: 196597-80-5

Purity: >98.0% (HPLC)

Appearance: White to Off-White Solid Powder

Intermediate of Ramelteon (CAS: 196597-26-9)

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Product Detail

Product Tags

Description:

Leading Manufacturer and Supplier
Intermediates of Ramelteon:
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	(S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride
Synonyms	Despropionyl Ramelteon Hydrochloride; (S)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride; (S)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine HCl; Ramelteon Impurity 15 HCl; Ramelteon Amine Impurity
CAS Number	196597-80-5
CAT Number	RF2888
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C13H17NO.HCl
Molecular Weight	239.74
Melting Point	270℃
Solubility in Water	Soluble in Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Solid Powder
Purity / Analysis Method	>98.0% (HPLC)
Loss on Drying	<1.00%
Single Impurity	<1.00%
Total Impurities	<2.00%
1 H NMR Spectrum	Consistent With Structure
Test Standard	Enterprise Standard
Usage	Intermediate of Ramelteon (CAS: 196597-26-9)

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

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Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

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Application:

(S)-2-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-yl)ethylamine Hydrochloride, also known as Despropionyl Ramelteon Hydrochloride (CAS: 196597-80-5) is an intermediate of Ramelteon (CAS: 196597-26-9). Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. The melatonin molecule wasmodified mainly by replacing the nitrogen of the indole ringwith a carbon to give an indane ring and by incorporating 5-methoxyl group in the indole ring into a more rigid furan ring. The selectivity of the resulting Ramelteon for MT1 receptor iseight times more than that of MT2 receptor. Unlike melatonin, it is more effective in initiating sleep (MT1 activity)rather than to readjust the circadian rhythm (MT2 activity). Itappears to be distinctly more efficacious than melatonin butless efficacious than benzodiazepines as a hypnotic. Importantly, this drug has no addiction liability (it is not acontrolled substance). As a result, it has recently been approvedfor the treatment of insomnia.