Diethylphosphonoacetic Acid CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory

Short Description:

Chemical Name: Diethylphosphonoacetic Acid

CAS: 3095-95-2

Purity: >99.5% (HPLC)

Appearance: Colorless Liquid

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

High Quality, Commercial Production

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Product Detail

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Description:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine CAS 314771-88-5

Chemical Properties:

Chemical Name	Diethylphosphonoacetic Acid
Synonyms	2-(Diethoxyphosphoryl)acetic Acid; (Diethoxyphosphinyl)acetic Acid; Diethyl Carboxymethylphosphonate; NSC 272281
CAS Number	3095-95-2
CAT Number	RF-PI2024
Stock Status	In Stock, Production Capacity 30MT/Month
Molecular Formula	(C2H5O)2P(O)CH2CO2H
Molecular Weight	196.14
Boiling Point	150℃/0.05 mmHg (lit.)
Density	1.220 g/mL at 25℃ (lit.)
Refractive Index	n20/D 1.445 (lit.)
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Colorless Liquid
Identification (HPLC)	The retention time of the main peak obtained from the sample is within 5% of the reference sample.
Purity / Analysis Method	>99.5% (HPLC)
Infrared Spectrum	Conforms to Structure
Proton NMR Spectrum	Conforms to Structure
Moisture (K.F)	<0.50%
Total Impurities	<0.50%
Test Standard	Enterprise Standard
Usage	Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Package & Storage:

Package: Fluorinated Bottle, 25kg/ Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

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Application:

Diethylphosphonoacetic Acid (CAS: 3095-95-2), Acts as a nucleophile for nucleophilic addition reactions for synthesis of allene epoxides Reactant for: Stereoselectivity studies of the Staudinger reaction; Enantioselective formation of diols via epoxidation and hydration reactions; Horner-Wadsworth-Emmons reactions; Remote chelation controlled Ireland-Claisen rearrangement; Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives; Used to make phosphonoester intermediates for intramolecular HEW reactions. Diethylphosphonoacetic Acid is an intermediate of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib Dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib Dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites.